Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TYRP1_HUMAN
Description:tyrosinase-related protein 1 [Source:HGNC Symbol;Acc:12450]
Location:chr9 p23
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S270LMGSRsNFDSTTyrosinasePhosphoSitePlus
S137NLLDLsKEEKNTyrosinasePhosphoSitePlus

Dephosphorylation site
TYRP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000373570Q21*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000373570A24SCOSMICLung Cancer

Differential expressed protein
TYRP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TYRP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
OTX1_HUMANTYRP1_HUMANTF -> target geneTRANSFAC
MITF_HUMANTYRP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TYRP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030669clathrin-coated endocytic vesicle membraneIDAcellular_component
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0042438melanin biosynthetic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010008endosome membraneIDAcellular_component
GO:0033162melanosome membraneIEAcellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0042470melanosomeISScellular_component
GO:0043438acetoacetic acid metabolic processIEAbiological_process
GO:0016716oxidoreductase activity, acting on paired donors, IEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0030318melanocyte differentiationIEAbiological_process
GO:0043473pigmentationIEAbiological_process
GO:0032438melanosome organizationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0006582melanin metabolic processIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0005507copper ion bindingIEAmolecular_function
GO:0016491oxidoreductase activityIEAmolecular_function


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