| UniProt/SwissProt ID: | OTX1_HUMAN |
| Description: | orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:8521] |
| Location: | chr2 p15 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T34 | VGYPAtPRKQR | PhosphoSitePlus | |
| Dephosphorylation site |
| OTX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000282549 | T46M | COSMIC | Pancreatic Cancer | ENSP00000282549 | D315E | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| OTX1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| OTX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| OTX1_HUMAN | TYRP1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| OTX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0022037 | metencephalon development | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0007275 | multicellular organismal development | NAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | NAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042472 | inner ear morphogenesis | IEA | biological_process |
| GO:0030901 | midbrain development | IEA | biological_process |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0048852 | diencephalon morphogenesis | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0009952 | anterior/posterior pattern specification | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |