Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TYOBP_HUMAN
Description:TYRO protein tyrosine kinase binding protein [Source:HGNC Symbol;Acc:12449]
Location:chr19 q13.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y91ETESPyQELQGPhosphoSitePlus; phosphoELM; RegPhos
Y91ETESPyQELQGSYKHPRD; phosphoELM; RegPhos
Y111NTQRPyYK___PhosphoSitePlus
Y91ETESPyQELQGSykRegPhos
Y112TQRPYyK____PhosphoSitePlus
Y102QRSDVySDLNTPhosphoSitePlus; RegPhos
Y90ETESPyQELQGSYKHPRD
S89ITETEsPYQELPhosphoSitePlus
Y102QRSDVySDLNTSYKHPRD; phosphoELM; RegPhos
Y102QRSDVySDLNTSykRegPhos
Y101QRSDVySDLNTSYKHPRD

Dephosphorylation site
TYOBP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262629R23CCOSMICSkin Cancer21984974

Differential expressed protein
TYOBP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TYOBP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KSYK_HUMANTYOBP_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANTYOBP_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0002281macrophage activation involved in immune responseIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006968cellular defense responseTASbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0002283neutrophil activation involved in immune responseIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0005887integral to plasma membraneTAScellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23