| UniProt/SwissProt ID: | TYDP2_HUMAN |
| Description: | tyrosyl-DNA phosphodiesterase 2 [Source:HGNC Symbol;Acc:17768] |
| Location: | chr6 p22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y139 | RGVCSyLALYS | Exo_endo_phos | PhosphoSitePlus |
| S254 | QEAPEsATVIF | Exo_endo_phos | PhosphoSitePlus |
| Y61 | RALNSyFEPPV | PhosphoSitePlus | |
| Y160 | PPYYSyLKKRS | Exo_endo_phos | PhosphoSitePlus |
| T88 | TYVDLtNEETT | PhosphoSitePlus | |
| Y158 | VIPPYySYLKK | Exo_endo_phos | PhosphoSitePlus |
| Y157 | EVIPPyYSYLK | Exo_endo_phos | PhosphoSitePlus |
| T92 | LTNEEtTDSTT | PhosphoSitePlus | |
| Dephosphorylation site |
| TYDP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000367440 | S69R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000367440 | E21K | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| TYDP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TYDP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KSYK_HUMAN | TYDP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | TYDP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K7_HUMAN | TYDP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | TYDP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TYDP2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006302 | double-strand break repair | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0070260 | 5'-tyrosyl-DNA phosphodiesterase activity | IDA | molecular_function |
| GO:0030145 | manganese ion binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0003697 | single-stranded DNA binding | IDA | molecular_function |
| GO:0000287 | magnesium ion binding | TAS | molecular_function |
| GO:0005730 | nucleolus | IEA | cellular_component |
| GO:0036317 | tyrosyl-RNA phosphodiesterase activity | IDA | molecular_function |
| GO:0004518 | nuclease activity | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003714 | transcription corepressor activity | TAS | molecular_function |