| UniProt/SwissProt ID: | TUT4_HUMAN |
| Description: | zinc finger, CCHC domain containing 11 [Source:HGNC Symbol;Acc:28981] |
| Location: | chr1 p32.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S831 | LKKELsQCNCI | PhosphoSitePlus; HPRD | |
| T1101 | QYLGYtMKVFA | PhosphoSitePlus | |
| S678 | IEDPFsVKRNV | PAP_assoc | PhosphoSitePlus |
| S847 | PDPDKsTGTDC | PhosphoSitePlus | |
| S356 | HLAALsVAVIE | PhosphoSitePlus | |
| S134 | EKSPKsPNSVK | PhosphoSitePlus | |
| S343 | ESELRsLPPPS | PhosphoSitePlus | |
| S137 | PKSPNsVKAEK | PhosphoSitePlus | |
| S574 | KWECNsSSATE | PhosphoSitePlus | |
| S773 | EMDCTsQRCII | PhosphoSitePlus; HPRD; phosphoELM | |
| Y1100 | VQYLGyTMKVF | PhosphoSitePlus | |
| T217 | SQKQQtCTDNT | PhosphoSitePlus | |
| T848 | DPDKStGTDCR | PhosphoSitePlus; HPRD | |
| S1384 | RQRNSsVAAAQ | PhosphoSitePlus | |
| Y1097 | DPRVQyLGYTM | PhosphoSitePlus | |
| S348 | SLPPPsPAHLA | PhosphoSitePlus | |
| S104 | KKFPNsPVKAE | PhosphoSitePlus | |
| T850 | DKSTGtDCRSN | PhosphoSitePlus; HPRD | |
| S1383 | ARQRNsSVAAA | PhosphoSitePlus | |
| S156 | EKVPSsPAEAE | PhosphoSitePlus | |
| Dephosphorylation site |
| TUT4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000257177 | F1147L | COSMIC | Melanoma | 21499247 | ENSP00000257177 | N744S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000257177 | Q1446* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000360599 | Q1445* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000360599 | Q1151H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000257177 | Q1151H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000257177 | R461Q | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000360599 | R461Q | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000257177 | G1286E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000348063 | *310S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000257177 | P495L | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| TUT4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TUT4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FYN_HUMAN | TUT4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TUT4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0070102 | interleukin-6-mediated signaling pathway | IEA | biological_process |
| GO:0016779 | nucleotidyltransferase activity | IEA | molecular_function |
| GO:0032755 | positive regulation of interleukin-6 production | IEA | biological_process |
| GO:0032088 | negative regulation of NF-kappaB transcription fac | IEA | biological_process |
| GO:0031054 | pre-miRNA processing | IMP | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0031123 | RNA 3'-end processing | IDA | biological_process |
| GO:0031664 | regulation of lipopolysaccharide-mediated signalin | IEA | biological_process |
| GO:0050265 | RNA uridylyltransferase activity | IDA | molecular_function |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0010586 | miRNA metabolic process | IEA | biological_process |
| GO:0001816 | cytokine production | IEA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010587 | miRNA catabolic process | IMP | biological_process |
| GO:0019827 | stem cell maintenance | IMP | biological_process |