Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRIO_HUMAN
Description:trio Rho guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:12303]
Location:chr5 p15.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S297FPKKNsGSGNASpectrinPhosphoSitePlus
T1545SELGVtEHVEGPHPhosphoSitePlus
S2440KDARAsLGTLPHPRD
S2417MKVLEsPRKGAPhosphoSitePlus; HPRD
S2208KKKGFsMPGFLPHPhosphoSitePlus
S2462LNSPLsSAVPSHPRD
S2391GPSAPsRRPPGPhosphoSitePlus
S2388PEAGPsAPSRRPhosphoSitePlus
S2467SSAVPsLGKEPHPRD
S2459ASPLNsPLSSAPhosphoSitePlus; HPRD
T1899LLVRPtSSETPPhosphoSitePlus
S1785PVRRLsSGKADPhosphoSitePlus
S2282LNALTsPIEYQPhosphoSitePlus; HPRD
S2495PASPAsRPGSFPhosphoSitePlus
S1459LEVMLsVPKRARhoGEFPhosphoSitePlus
T1903PTSSEtPSAAEPhosphoSitePlus; HPRD
T2513SLQRQtPRHAAPhosphoSitePlus
T1844PTSSEtPSAAEphosphoELM; RegPhos
Y1228AVDKRyRDFSLSpectrinPhosphoSitePlus
T1824DDSAAtPQDETPhosphoSitePlus
T724TTLQVtVNVIKSpectrinPhosphoSitePlus
S1900LVRPTsSETPSPhosphoSitePlus
Y2796NFDSFySEVAEPhosphoSitePlus
Y2058RRLHMyIAYCQRhoGEFPhosphoSitePlus
S1779RKWLTsPVRRLPhosphoSitePlus; HPRD
S116LACIPsEEVCKCRAL_TRIOPhosphoSitePlus
T2625ENPDGtLKKSTPhosphoSitePlus
S299KKNSGsGNADLSpectrinPhosphoSitePlus
Y2737NFDSFySEVAEFAKRegPhos
Y2796NFDSFySEVAEPTK2HPRD
Y2286TSPIEyQRNHSPhosphoSitePlus
Y2737NFDSFySEVAEphosphoELM; RegPhos
S2455RAGAAsPLNSPPhosphoSitePlus; HPRD
S1809REVRKsADAGSPhosphoSitePlus
S2492SSIPAsPASRPPhosphoSitePlus
Y2659KLENGyRKSREPhosphoSitePlus
T1778LRKWLtSPVRRPhosphoSitePlus
T1486SELGVtEHVEGphosphoELM; RegPhos
Y2075HIVSEyIDTFFRhoGEFPhosphoSitePlus
S1901VRPTSsETPSAPhosphoSitePlus
S1847GTLSKsSSSGMPhosphoSitePlus
S1854SSGMQsCGEEEPhosphoSitePlus
S2429NASGSsPDAPAPhosphoSitePlus; HPRD
S2508PGDSDsLQRQTPhosphoSitePlus
S1786VRRLSsGKADGPhosphoSitePlus
S1814SADAGsQKDSDPhosphoSitePlus
T2281FLNALtSPIEYHPRD

Dephosphorylation site
TRIO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339299G2854fs*16COSMICIntestines Cancer
ENSP00000339299L364VBIOMARTBreast Cancer21930507, 21930502
ENSP00000339299T1317MCOSMICMelanoma
ENSP00000339299D658NCOSMICSkin Cancer21984974
ENSP00000339299N1671KCOSMICOvarian Cancer21720365
ENSP00000339299G53ECOSMICMelanoma
ENSP00000339299D2995NBIOMARTBreast Cancer21930507, 21930502
ENSP00000339291N167SBIOMARTBreast Cancer21930507, 21930502
ENSP00000339299N2668SBIOMARTBreast Cancer21930507, 21930502
ENSP00000339299R1078GCOSMICOvarian Cancer21720365
ENSP00000339299P2378LCOSMICSkin Cancer21984974
ENSP00000339299A3042VCOSMICIntestines Cancer
ENSP00000339299N1121KCOSMICHead and Neck Cancer21798893
ENSP00000339299D2176ECOSMICOvarian Cancer21720365
ENSP00000339299V698MCOSMICHead and Neck Cancer21798893
ENSP00000339299I1576VCOSMICGastric Cancer21097718
ENSP00000339291D494NBIOMARTBreast Cancer21930507, 21930502
ENSP00000339299G2575ECOSMICMelanoma
ENSP00000339299R2876CCOSMICBreast Cancer15908952
ENSP00000339299N3003SCOSMICRenal Cancer20054297
ENSP00000339299V1978MCOSMICMelanoma
ENSP00000339299M1129ICOSMICHead and Neck Cancer21798897

Differential expressed protein
TRIO_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TRIO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTRIO_HUMANkinase -> substrateRegPhos
FAK1_HUMANTRIO_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
TRIO_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005085guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007185transmembrane receptor protein tyrosine phosphatasTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0016020membraneIEAcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23