Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TREX1_HUMAN
Description:three prime repair exonuclease 1 [Source:HGNC Symbol;Acc:12269]
Location:chr3 p21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S222LERASsPSEHGHPRD; phosphoELM
S261TTRNTsPSLGEHPRD
Y238SLGSIyTRLYGRNase_TPhosphoSitePlus
S78PGKACsPAASEHPRD
S133PGKACsPAASERNase_TPhosphoSitePlus
S316TTRNTsPSLGEPhosphoSitePlus; HPRD; phosphoELM
S167LERASsPSEHGHPRD
S133PGKACsPAASEHPRD; phosphoELM

Dephosphorylation site
TREX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296443D102NBIOMARTBreast Cancer21930507, 21930502
ENSP00000390478G235SCOSMICSkin Cancer21984974
ENSP00000415972D92NBIOMARTBreast Cancer21930507, 21930502
ENSP00000390478K121MCOSMICSkin Cancer21984974
ENSP00000392569D102NBIOMARTBreast Cancer21930507, 21930502
ENSP00000390478K121*COSMICSkin Cancer21984974
ENSP00000390478D157NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TREX1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TREX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ATR_HUMANTREX1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04623Cytosolic DNA-sensing pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032407MutSalpha complex bindingIDAmolecular_function
GO:0006281DNA repairTASbiological_process
GO:0046872metal ion bindingNASmolecular_function
GO:00082963'-5'-exodeoxyribonuclease activityTASmolecular_function
GO:0006298mismatch repairNASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0003697single-stranded DNA bindingIEAmolecular_function
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0008219cell deathIEAbiological_process
GO:0035458cellular response to interferon-betaIEAbiological_process
GO:0005635nuclear envelopeNAScellular_component
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0006260DNA replicationNASbiological_process
GO:0008853exodeoxyribonuclease III activityIEAmolecular_function
GO:00084083'-5' exonuclease activityIDAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0004527exonuclease activityIEAmolecular_function
GO:0032558adenyl deoxyribonucleotide bindingIEAmolecular_function
GO:0006310DNA recombinationNASbiological_process
GO:0032405MutLalpha complex bindingIDAmolecular_function


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