Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TOB1_HUMAN
Description:transducer of ERBB2, 1 [Source:HGNC Symbol;Acc:11979]
Location:chr17 q21.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S205KVARTsPINLGPhosphoSitePlus; HPRD; phosphoELM
Y40LLKKKyEGHWYBTGPhosphoSitePlus
S152SSVSSsPSPPFMAPK1HPRD
S154VSSSPsPPFGHMAPK1HPRD
S164HSAAVsPTFMPMAPK1HPRD
T204NKVARtSPINLPhosphoSitePlus; HPRD
S152SSVSSsPSPPFPhosphoSitePlus
S164HSAAVsPTFMPPhosphoSitePlus
S154VSSSPsPPFGHPhosphoSitePlus

Dephosphorylation site
TOB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000427695R170WCOSMICHead and Neck Cancer21984974
ENSP00000268957R170WCOSMICHead and Neck Cancer21984974
ENSP00000268957K48NCOSMICIntestines Cancer
ENSP00000427695K48NCOSMICIntestines Cancer

Differential expressed protein
TOB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TOB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANTOB1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03018RNA degradation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0030514negative regulation of BMP signaling pathwayIEAbiological_process
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0046332SMAD bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007184SMAD protein import into nucleusIEAbiological_process
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component


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