| UniProt/SwissProt ID: | TOB1_HUMAN |
| Description: | transducer of ERBB2, 1 [Source:HGNC Symbol;Acc:11979] |
| Location: | chr17 q21.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S205 | KVARTsPINLG | PhosphoSitePlus; HPRD; phosphoELM | |
| Y40 | LLKKKyEGHWY | BTG | PhosphoSitePlus |
| S152 | SSVSSsPSPPF | MAPK1 | HPRD |
| S154 | VSSSPsPPFGH | MAPK1 | HPRD |
| S164 | HSAAVsPTFMP | MAPK1 | HPRD |
| T204 | NKVARtSPINL | PhosphoSitePlus; HPRD | |
| S152 | SSVSSsPSPPF | PhosphoSitePlus | |
| S164 | HSAAVsPTFMP | PhosphoSitePlus | |
| S154 | VSSSPsPPFGH | PhosphoSitePlus | |
| Dephosphorylation site |
| TOB1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000427695 | R170W | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000268957 | R170W | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000268957 | K48N | COSMIC | Intestines Cancer | ENSP00000427695 | K48N | COSMIC | Intestines Cancer |
| Differential expressed protein |
| TOB1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TOB1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | TOB1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03018 | RNA degradation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0030514 | negative regulation of BMP signaling pathway | IEA | biological_process |
| GO:0045668 | negative regulation of osteoblast differentiation | IEA | biological_process |
| GO:0046332 | SMAD binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007184 | SMAD protein import into nucleus | IEA | biological_process |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0003714 | transcription corepressor activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |