Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNR8_HUMAN
Description:tumor necrosis factor receptor superfamily, member 8 [Source:HGNC Symbol;Acc:11923]
Location:chr1 p36.22
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y518KIEKIyIMKADPhosphoSitePlus
T445PRRSStQLRSGPhosphoSitePlus; HPRD
Y479SVGAAyLESLPPhosphoSitePlus
S444RPRRSsTQLRSPhosphoSitePlus; HPRD
S449STQLRsGASVTPhosphoSitePlus
S496AGGPSsPRDLPPhosphoSitePlus
S443SRPRRsSTQLRPhosphoSitePlus
T454SGASVtEPVAEPhosphoSitePlus; HPRD
Y560DHTPHyPEQETPhosphoSitePlus
S452LRSGAsVTEPVPhosphoSitePlus

Dephosphorylation site
TNR8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263932V93MCOSMICPancreatic Cancer
ENSP00000263932N32TBIOMARTBreast Cancer21930507, 21930502
ENSP00000263932P215SCOSMICMelanoma20016485
ENSP00000398337*133KCOSMICMelanoma21499247

Differential expressed protein
TNR8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TNR8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNFL8_HUMANTNR8_HUMANligand -> receptorHPMR
TNFL8_HUMANTNR8_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0033209tumor necrosis factor-mediated signaling pathwayRCAbiological_process
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0045556positive regulation of TRAIL biosynthetic processIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0042535positive regulation of tumor necrosis factor biosyIDAbiological_process
GO:0005031tumor necrosis factor-activated receptor activityRCAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0008285negative regulation of cell proliferationTASbiological_process


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