| UniProt/SwissProt ID: | TNR8_HUMAN |
| Description: | tumor necrosis factor receptor superfamily, member 8 [Source:HGNC Symbol;Acc:11923] |
| Location: | chr1 p36.22 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y518 | KIEKIyIMKAD | PhosphoSitePlus | |
| T445 | PRRSStQLRSG | PhosphoSitePlus; HPRD | |
| Y479 | SVGAAyLESLP | PhosphoSitePlus | |
| S444 | RPRRSsTQLRS | PhosphoSitePlus; HPRD | |
| S449 | STQLRsGASVT | PhosphoSitePlus | |
| S496 | AGGPSsPRDLP | PhosphoSitePlus | |
| S443 | SRPRRsSTQLR | PhosphoSitePlus | |
| T454 | SGASVtEPVAE | PhosphoSitePlus; HPRD | |
| Y560 | DHTPHyPEQET | PhosphoSitePlus | |
| S452 | LRSGAsVTEPV | PhosphoSitePlus | |
| Dephosphorylation site |
| TNR8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263932 | V93M | COSMIC | Pancreatic Cancer | ENSP00000263932 | N32T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263932 | P215S | COSMIC | Melanoma | 20016485 | ENSP00000398337 | *133K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| TNR8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TNR8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNFL8_HUMAN | TNR8_HUMAN | ligand -> receptor | HPMR |
| TNFL8_HUMAN | TNR8_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043065 | positive regulation of apoptotic process | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | RCA | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0045556 | positive regulation of TRAIL biosynthetic process | IDA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0071260 | cellular response to mechanical stimulus | IEP | biological_process |
| GO:0042535 | positive regulation of tumor necrosis factor biosy | IDA | biological_process |
| GO:0005031 | tumor necrosis factor-activated receptor activity | RCA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |