| UniProt/SwissProt ID: | TNFL8_HUMAN |
| Description: | tumor necrosis factor (ligand) superfamily, member 8 [Source:HGNC Symbol;Acc:11938] |
| Location: | chr9 q32 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S67 | VQRTDsIPNSP | PhosphoSitePlus | |
| S71 | DSIPNsPDNVP | PhosphoSitePlus | |
| Dephosphorylation site |
| TNFL8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000223795 | I214R | COSMIC | Melanoma | 21499247 | ENSP00000223795 | G80E | COSMIC | Melanoma | 21499247 | ENSP00000223795 | D215N | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| TNFL8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TNFL8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNFL8_HUMAN | TNR8_HUMAN | ligand -> receptor | HPMR |
| TNFL8_HUMAN | TNR8_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0006917 | induction of apoptosis | TAS | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0043374 | CD8-positive, alpha-beta T cell differentiation | IEA | biological_process |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0050830 | defense response to Gram-positive bacterium | IEA | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |