Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNFL8_HUMAN
Description:tumor necrosis factor (ligand) superfamily, member 8 [Source:HGNC Symbol;Acc:11938]
Location:chr9 q32
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S67VQRTDsIPNSPPhosphoSitePlus
S71DSIPNsPDNVPPhosphoSitePlus

Dephosphorylation site
TNFL8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000223795I214RCOSMICMelanoma21499247
ENSP00000223795G80ECOSMICMelanoma21499247
ENSP00000223795D215NCOSMICOvarian Cancer21720365

Differential expressed protein
TNFL8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TNFL8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNFL8_HUMANTNR8_HUMANligand -> receptorHPMR
TNFL8_HUMANTNR8_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007267cell-cell signalingTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0005102receptor bindingTASmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0005615extracellular spaceIEAcellular_component
GO:0005164tumor necrosis factor receptor bindingIEAmolecular_function
GO:0006917induction of apoptosisTASbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043374CD8-positive, alpha-beta T cell differentiationIEAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0006955immune responseIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process


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