Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNR5_HUMAN
Description:CD40 molecule, TNF receptor superfamily member 5 [Source:HGNC Symbol;Acc:11919]
Location:chr20 q13.12
Node attribute:PPI(target); receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T254APVQEtLHGCQPhosphoSitePlus; phosphoELM
T223VAKKPtNKAPHGlycophorin_APhosphoSitePlus

Dephosphorylation site
TNR5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361359Y82HCOSMICLung Cancer20668451
ENSP00000361359G266DCOSMICMelanoma
ENSP00000361359S39THPIUrinary Bladder Cancer2463309
ENSP00000361359S35GHPIUrinary Bladder Cancer2463309
ENSP00000361359C26QHPIUrinary Bladder Cancer2463309

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000361359Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
TNR5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNFC_HUMANTNR5_HUMANligand -> receptorHPMR
CD40L_HUMANTNR5_HUMANligand -> receptorHPMR
CD40L_HUMANTNR5_HUMANotherKEGG
IRF3_HUMANTNR5_HUMANTF -> target geneKEGG
AKNA_HUMANTNR5_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05416Viral myocarditis
hsa05202Transcriptional misregulation in cancer
hsa04060Cytokine-cytokine receptor interaction
hsa05340Primary immunodeficiency
hsa05145Toxoplasmosis
hsa05166HTLV-I infection
hsa04064NF-kappa B signaling pathway
hsa05330Allograft rejection
hsa05144Malaria
hsa04672Intestinal immune network for IgA production
hsa05320Autoimmune thyroid disease
hsa05169Epstein-Barr virus infection
hsa05310Asthma
hsa04620Toll-like receptor signaling pathway
hsa05322Systemic lupus erythematosus
hsa04514Cell adhesion molecules (CAMs)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0048304positive regulation of isotype switching to IgG isIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0042100B cell proliferationNASbiological_process
GO:0042511positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0002768immune response-regulating cell surface receptor sIEAbiological_process
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0009897external side of plasma membraneIEAcellular_component
GO:0004872receptor activityTASmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0035631CD40 receptor complexIEAcellular_component
GO:0035631CD40 receptor complexISScellular_component
GO:0032855positive regulation of Rac GTPase activityIMPbiological_process
GO:0050776regulation of immune responseIEAbiological_process
GO:0090037positive regulation of protein kinase C signaling IMPbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:2000353positive regulation of endothelial cell apoptotic IDAbiological_process
GO:0042113B cell activationIEAbiological_process
GO:0043089positive regulation of Cdc42 GTPase activityIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0051023regulation of immunoglobulin secretionIEAbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0032735positive regulation of interleukin-12 productionIEAbiological_process
GO:0006874cellular calcium ion homeostasisIMPbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0043406positive regulation of MAP kinase activityIMPbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0030168platelet activationNASbiological_process
GO:0005886plasma membraneISScellular_component
GO:0005887integral to plasma membraneTAScellular_component