| UniProt/SwissProt ID: | AKNA_HUMAN |
| Description: | AT-hook transcription factor [Source:HGNC Symbol;Acc:24108] |
| Location: | chr9 q32 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S997 | QRYLSsPSGPL | PhosphoSitePlus | |
| S1160 | QRARSsSVPRE | PhosphoSitePlus | |
| T258 | SVARAtPMEFQ | PhosphoSitePlus | |
| S839 | TEKMVsMKPPG | PhosphoSitePlus; HPRD; phosphoELM | |
| S1159 | RQRARsSSVPR | PhosphoSitePlus | |
| S52 | FPNATsPELLE | PhosphoSitePlus; HPRD | |
| S886 | ASHQSsMTSLE | PhosphoSitePlus | |
| T539 | SPSSLtSMPTL | PhosphoSitePlus | |
| S1303 | TRRKAsSTPSP | PhosphoSitePlus | |
| T982 | IPRRAtEPSTP | PhosphoSitePlus | |
| Y376 | PKDESyRPPKS | PhosphoSitePlus | |
| Y1219 | TFRGQyTGHEY | PhosphoSitePlus | |
| Y450 | QLQEDyHRLLT | PhosphoSitePlus | |
| S40 | RSSSQsWEEER | PhosphoSitePlus | |
| S1387 | RRHRHsIQLDL | PhosphoSitePlus | |
| S1161 | RARSSsVPREV | PhosphoSitePlus | |
| Y758 | QMEQVyHGLME | PhosphoSitePlus | |
| S272 | APPAQsPQHAT | PhosphoSitePlus | |
| S1307 | ASSTPsPKQRS | PhosphoSitePlus | |
| S184 | SGDKLsEHSEV | PhosphoSitePlus | |
| S1172 | LRLSLsSESEL | PhosphoSitePlus | |
| T631 | AGSKGtPGRFD | PhosphoSitePlus | |
| S159 | GHGNTsPMALG | PhosphoSitePlus | |
| Y1224 | YTGHEyHVLSP | PhosphoSitePlus | |
| S196 | PSVELsPARSW | PhosphoSitePlus | |
| T284 | RWRREtTRFFC | PhosphoSitePlus | |
| S534 | ARGDLsPSSLT | PhosphoSitePlus | |
| S996 | AQRYLsSPSGP | PhosphoSitePlus | |
| T51 | LFPNAtSPELL | PhosphoSitePlus; HPRD | |
| S1228 | EYHVLsPKAVP | PhosphoSitePlus | |
| S38 | VDRSSsQSWEE | PhosphoSitePlus | |
| T986 | ATEPStPRSQA | PhosphoSitePlus | |
| T1220 | FRGQYtGHEYH | PhosphoSitePlus | |
| S1422 | RQMRSsLSADL | PhosphoSitePlus | |
| S848 | PGFQAsLARDG | PhosphoSitePlus; HPRD; phosphoELM | |
| Y356 | RGQLNyPLPDF | PhosphoSitePlus | |
| Dephosphorylation site |
| AKNA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363201 | T420M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000363201 | P226R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000303769 | R647H | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000363201 | T1060R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000303769 | E930K | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000303769 | P226R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000309222 | T420M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000303769 | G248D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363201 | R647H | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000363188 | T339M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000363201 | E930K | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000303769 | T1060R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000303769 | T420M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000363201 | G248D | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| AKNA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AKNA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKNA_HUMAN | TNR5_HUMAN | TF -> target gene | TRANSFAC |
| AKNA_HUMAN | CD40L_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| AKNA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |