Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLR9_HUMAN
Description:toll-like receptor 9 [Source:HGNC Symbol;Acc:15633]
Location:chr3 p21.2
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y345NLSFNyQKRVSLRR_4PhosphoSitePlus
S423RYVDLsDNRISLRR_4PhosphoSitePlus
Y419FPGLRyVDLSDLRR_4PhosphoSitePlus

Dephosphorylation site
TLR9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353874E729KCOSMICMelanoma21499247
ENSP00000353874T933MSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000353874G514SCOSMICMelanoma20016485
ENSP00000353874T933MHPIColorectal Cancer16959974
ENSP00000353874R901HSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000353874R901HHPIColorectal Cancer16959974
ENSP00000353874A365VCOSMICSkin Cancer21984974

Differential expressed protein
TLR9_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TLR9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TLR9_HUMANMYD88_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05144Malaria
hsa05168Herpes simplex infection
hsa05152Tuberculosis
hsa04620Toll-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05143African trypanosomiasis
hsa05162Measles

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034122negative regulation of toll-like receptor signalinIDAbiological_process
GO:0032755positive regulation of interleukin-6 productionIDAbiological_process
GO:0045356positive regulation of interferon-alpha biosynthetIDAbiological_process
GO:0032717negative regulation of interleukin-8 productionIDAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0032735positive regulation of interleukin-12 productionISSbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0030277maintenance of gastrointestinal epitheliumISSbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0032088negative regulation of NF-kappaB transcription facIDAbiological_process
GO:0005768endosomeISScellular_component
GO:0051770positive regulation of nitric-oxide synthase biosyISSbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0007165signal transductionIEAbiological_process
GO:0034123positive regulation of toll-like receptor signalinIDAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0046330positive regulation of JNK cascadeICbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0045359positive regulation of interferon-beta biosynthetiIDAbiological_process
GO:0032760positive regulation of tumor necrosis factor produISSbiological_process
GO:0050729positive regulation of inflammatory responseICbiological_process
GO:0002237response to molecule of bacterial originTASbiological_process
GO:0005783endoplasmic reticulumISScellular_component
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0045078positive regulation of interferon-gamma biosynthetIDAbiological_process
GO:0032757positive regulation of interleukin-8 productionIDAbiological_process
GO:0032715negative regulation of interleukin-6 productionISSbiological_process
GO:0035197siRNA bindingIMPmolecular_function
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0032009early phagosomeISScellular_component
GO:0042346positive regulation of NF-kappaB import into nucleIDAbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0032728positive regulation of interferon-beta productionISSbiological_process
GO:0036020endolysosome membraneTAScellular_component
GO:0005149interleukin-1 receptor bindingIPImolecular_function
GO:0042742defense response to bacteriumNASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:0043507positive regulation of JUN kinase activityIDAbiological_process
GO:0032722positive regulation of chemokine productionIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005576extracellular regionNAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0032733positive regulation of interleukin-10 productionISSbiological_process
GO:0016324apical plasma membraneIDAcellular_component
GO:0032741positive regulation of interleukin-18 productionISSbiological_process
GO:0005764lysosomeISScellular_component
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process