Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLR5_HUMAN
Description:toll-like receptor 5 [Source:HGNC Symbol;Acc:11851]
Location:chr1 q41
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y108GSSKIyFLHPDLRR_8PhosphoSitePlus
S805LMKHQsIRGFVTIRPhosphoSitePlus
Y798GSLSQyQLMKHTIRPhosphoSitePlus
Y161QIRSLyLHPSFLRR_8PhosphoSitePlus

Dephosphorylation site
TLR5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355846A771TCOSMICHead and Neck Cancer21798893
ENSP00000355846Y108*COSMICOvarian Cancer21720365
ENSP00000355846M1VCOSMICLung Cancer20668451
ENSP00000355846E731DCOSMICMelanoma21499247

Differential expressed protein
TLR5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TLR5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TLR5_HUMANMYD88_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05134Legionellosis
hsa04620Toll-like receptor signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0034123positive regulation of toll-like receptor signalinIDAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0006954inflammatory responseIEAbiological_process
GO:0005149interleukin-1 receptor bindingIPImolecular_function
GO:0032757positive regulation of interleukin-8 productionIDAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0016021integral to membraneIEAcellular_component


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