| UniProt/SwissProt ID: | TLR5_HUMAN |
| Description: | toll-like receptor 5 [Source:HGNC Symbol;Acc:11851] |
| Location: | chr1 q41 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y108 | GSSKIyFLHPD | LRR_8 | PhosphoSitePlus |
| S805 | LMKHQsIRGFV | TIR | PhosphoSitePlus |
| Y798 | GSLSQyQLMKH | TIR | PhosphoSitePlus |
| Y161 | QIRSLyLHPSF | LRR_8 | PhosphoSitePlus |
| Dephosphorylation site |
| TLR5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355846 | A771T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000355846 | Y108* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000355846 | M1V | COSMIC | Lung Cancer | 20668451 | ENSP00000355846 | E731D | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| TLR5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TLR5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TLR5_HUMAN | MYD88_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05134 | Legionellosis |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa05132 | Salmonella infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |
| GO:0071260 | cellular response to mechanical stimulus | IEP | biological_process |
| GO:0034123 | positive regulation of toll-like receptor signalin | IDA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0005149 | interleukin-1 receptor binding | IPI | molecular_function |
| GO:0032757 | positive regulation of interleukin-8 production | IDA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |