| UniProt/SwissProt ID: | TLK1_HUMAN |
| Description: | tousled-like kinase 1 [Source:HGNC Symbol;Acc:11841] |
| Location: | chr2 q31.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S744 | RRSNSsGNLHM | HPRD | |
| T179 | SHSHStPSSSV | HPRD; RegPhos | |
| S741 | PHMRRsNSSGN | HPRD | |
| S743 | MRRSNsSGNLH | CHK1 | phosphoELM; RegPhos |
| S743 | MRRSNsSGNLH | RegPhos | |
| S158 | QGGNGsSPVRG | HPRD | |
| S133 | ENQNEsSQGKS | PhosphoSitePlus | |
| S138 | SSQGKsIGGRG | PhosphoSitePlus | |
| S159 | GGNGSsPVRGI | HPRD; phosphoELM; RegPhos; SysPTM | |
| S743 | MRRSNsSGNLH | CHEK1 | HPRD |
| S190 | RPNSPsPTALA | HPRD; RegPhos | |
| Dephosphorylation site |
| TLK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TLK1_HUMAN do not have mutation site. |
| Differential expressed protein |
| TLK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TLK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | TLK1_HUMAN | kinase -> substrate | RegPhos |
| CHK1_HUMAN | TLK1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| TLK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0006974 | response to DNA damage stimulus | IEA | biological_process |
| GO:0006886 | intracellular protein transport | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016568 | chromatin modification | IEA | biological_process |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0035556 | intracellular signal transduction | IDA | biological_process |
| GO:0001672 | regulation of chromatin assembly or disassembly | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |