Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TIE2_HUMAN
Description:TEK tyrosine kinase, endothelial [Source:HGNC Symbol;Acc:11724]
Location:chr9 p21.2
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y899HRGYLyLAIEYPkinase_TyrPhosphoSitePlus
Y1108VNTTLyEKFTYTIE2phosphoELM
Y1102EERKTyVNTTLTEKHPRD
Y992RGQEVyVKKTMPkinase_TyrPhosphoSitePlus
Y1102EERKTyVNTTLTie2RegPhos
S1119AGIDCsAEEAARegPhos
Y1108VNTTLyEKFTYTie2RegPhos
T996VYVKKtMGRLPPkinase_TyrPhosphoSitePlus
Y897CEHRGyLYLAITIE2RegPhos
Y992RGQEVyVKKTMTIE2phosphoELM
Y1102EERKTyVNTTLPhosphoSitePlus; phosphoELM
Y1113YEKFTyAGIDCTie2RegPhos
Y816PDPTIyPVLDWPhosphoSitePlus
Y897CEHRGyLYLAIphosphoELM; RegPhos
Y976LVGENyVAKIAPkinase_TyrPhosphoSitePlus
T115AIRIRtMKMRQIg_Tie2_1PhosphoSitePlus
Y992RGQEVyVKKTMHPRD; phosphoELM; RegPhos
Y1113YEKFTyAGIDCPhosphoSitePlus; phosphoELM
S142DNVNIsFKKVLPhosphoSitePlus
Y1048TCAELyEKLPQHPRD; phosphoELM; RegPhos
Y897CEHRGyLYLAIPkinase_TyrPhosphoSitePlus
Y992RGQEVyVKKTMautocatalysisRegPhos
S164GSFIHsVPRHEPhosphoSitePlus
S1119AGIDCsAEEHPRD
Y1108VNTTLyEKFTYPhosphoSitePlus; HPRD; RegPhos
Y1048TCAELyEKLPQPkinase_TyrPhosphoSitePlus
Y1113YEKFTyAGIDCTIE2phosphoELM
Y992RGQEVyVKKTMTie2RegPhos
Y1102EERKTyVNTTLTIE2phosphoELM; RegPhos
Y1048TCAELyEKLPQTie2RegPhos
Y1048TCAELyEKLPQTIE2phosphoELM
Y897CEHRGyLYLAITEKHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1108TYVNTTLyEKFTYAGPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369375R522CCOSMICSkin Cancer21984974
ENSP00000430233K117NBIOMARTBreast Cancer21930507, 21930502
ENSP00000369375R209QCOSMICBreast Cancer20668451
ENSP00000430233T1106MTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369375F203YTCGAOvarian Cancer21720365, 18772890
ENSP00000369375V1014LTCGAOvarian Cancer21720365, 18772890
ENSP00000369375E791*COSMICLung Cancer20668451
ENSP00000369375E1109DCOSMICLung Cancer20668451
ENSP00000369375R918LCOSMICLung Cancer20668451
ENSP00000430233F203YTCGAOvarian Cancer21720365, 18772890
ENSP00000369375S658YCOSMICHead and Neck Cancer21798893
ENSP00000369375G305CCOSMICSkin Cancer21984974
ENSP00000369375T1106MTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369375D137NCOSMICSkin Cancer21984974
ENSP00000369375N603KBIOMARTBreast Cancer21930507, 21930502
ENSP00000430233Q346PTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000430233V1014LTCGAOvarian Cancer21720365, 18772890
ENSP00000369375Q346PTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000369375L898FCOSMICBreast Cancer20668451
ENSP00000369375L601PCOSMICHead and Neck Cancer21798893
ENSP00000369375Y1015CBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TIE2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TIE2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANGP1_HUMANTIE2_HUMANligand -> receptorHPMR
ANGP2_HUMANTIE2_HUMANligand -> receptorHPMR
ZAGL2_HUMANTIE2_HUMANkinase -> substrateRegPhos
TIE2_HUMANTIE2_HUMANkinase -> substrateRegPhos
PTN11_HUMANTIE2_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05323Rheumatoid arthritis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005925focal adhesionIEAcellular_component
GO:0051259protein oligomerizationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0016337cell-cell adhesionIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0005911cell-cell junctionIDAcellular_component
GO:0034446substrate adhesion-dependent cell spreadingIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043114regulation of vascular permeabilityTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0004872receptor activityTASmolecular_function
GO:0001938positive regulation of endothelial cell proliferatTASbiological_process
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0045765regulation of angiogenesisIEAbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0004872receptor activityIEAmolecular_function
GO:0005884actin filamentIDAcellular_component
GO:2000351regulation of endothelial cell apoptotic processTASbiological_process
GO:0007507heart developmentISSbiological_process
GO:0005902microvillusIDAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0016324apical plasma membraneIDAcellular_component
GO:0045785positive regulation of cell adhesionIEAbiological_process
GO:0002040sprouting angiogenesisIMPbiological_process
GO:2000251positive regulation of actin cytoskeleton reorganiIMPbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0072012glomerulus vasculature developmentISSbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0032878regulation of establishment or maintenance of cellIMPbiological_process
GO:0060347heart trabecula formationISSbiological_process
GO:0050728negative regulation of inflammatory responseTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0001725stress fiberIDAcellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0014068positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0016525negative regulation of angiogenesisIMPbiological_process
GO:0048014Tie receptor signaling pathwayIDAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0010740positive regulation of intracellular protein kinasIMPbiological_process
GO:2000352negative regulation of endothelial cell apoptotic ISSbiological_process
GO:0030097hemopoiesisIEAbiological_process
GO:0060216definitive hemopoiesisTASbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0045121membrane raftIDAcellular_component
GO:0045766positive regulation of angiogenesisIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005887integral to plasma membraneIDAcellular_component
GO:0009925basal plasma membraneIDAcellular_component
GO:0001525angiogenesisISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0051894positive regulation of focal adhesion assemblyIMPbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0030334regulation of cell migrationIEAbiological_process
GO:0001935endothelial cell proliferationISSbiological_process
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIEAbiological_process