| UniProt/SwissProt ID: | THOC1_HUMAN |
| Description: | THO complex 1 [Source:HGNC Symbol;Acc:19070] |
| Location: | chr18 p11.32 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T4 | PLFS | HPRD | |
| T439 | GNEELtRLWNL | efThoc1 | PhosphoSitePlus |
| S2 | TPPL | HPRD; phosphoELM; SysPTM | |
| S315 | LQLSDsNFRRH | efThoc1 | PhosphoSitePlus |
| S2 | ____MsPTPPL | PhosphoSitePlus; SysPTM | |
| S560 | LKENEsPDVRR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T439 | GNEELtRLWNL | HPRD | |
| S313 | MDLQLsDSNFR | efThoc1 | PhosphoSitePlus |
| Y274 | AVFKSyKLDDT | efThoc1 | PhosphoSitePlus |
| S657 | DNET | HPRD | |
| T542 | SEEIKtGEDED | PhosphoSitePlus | |
| T428 | LGKGPtKKILM | efThoc1 | PhosphoSitePlus |
| Dephosphorylation site |
| THOC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| THOC1_HUMAN do not have mutation site. |
| Differential expressed protein |
| THOC1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| THOC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FRK_HUMAN | THOC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| THOC1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016363 | nuclear matrix | IEA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0000445 | THO complex part of transcription export complex | IDA | cellular_component |
| GO:0006406 | mRNA export from nucleus | IDA | biological_process |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0008380 | RNA splicing | IEA | biological_process |
| GO:0006915 | apoptotic process | IDA | biological_process |
| GO:0000346 | transcription export complex | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0046784 | intronless viral mRNA export from host nucleus | IDA | biological_process |
| GO:0000347 | THO complex | IDA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0006397 | mRNA processing | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032784 | regulation of DNA-dependent transcription, elongat | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016607 | nuclear speck | IEA | cellular_component |