Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TGIF1_HUMAN
Description:TGFB-induced factor homeobox 1 [Source:HGNC Symbol;Acc:11776]
Location:chr18 p11.31
Node attribute:ubiquitination(target); TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S291SPKPSsPGSVLHPRD
S179PSSPGsVLARPHPRD
S165PSSPGsVLARPHPRD
S294PSSPGsVLARPPhosphoSitePlus; HPRD
S140GIVAAsGSETEPhosphoSitePlus
S176SPKPSsPGSVLHPRD
S162SPKPSsPGSVLHPRD
S142VAASGsETEDEPhosphoSitePlus
S286LGRPLsPKPSSPhosphoSitePlus; HPRD
S115WELPRsPSQGAPhosphoSitePlus
S171LGRPLsPKPSSHPRD
T144ASGSEtEDEDSPhosphoSitePlus
S157LGRPLsPKPSSHPRD

Dephosphorylation site
TGIF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000327959V176LCOSMICOvarian Cancer21720365
ENSP00000327959P116ACOSMICHead and Neck Cancer21798893

Differential expressed protein
TGIF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TGIF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ITCH_HUMANTGIF1_HUMANubiquitinationNetPath
TGIF1_HUMANDRD1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TGIF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0048387negative regulation of retinoic acid receptor signIEAbiological_process
GO:0060041retina development in camera-type eyeIEAbiological_process
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0048146positive regulation of fibroblast proliferationIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0010470regulation of gastrulationIEAbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0038092nodal signaling pathwayIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003714transcription corepressor activityTASmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003682chromatin bindingIEAmolecular_function
GO:0070410co-SMAD bindingIEAmolecular_function
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0010629negative regulation of gene expressionIEAbiological_process


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