Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TGFA_HUMAN
Description:transforming growth factor, alpha [Source:HGNC Symbol;Acc:11765]
Location:chr2 p13.3
Node attribute:PPI(source); ligand; gene

Phosphorylation site
TGFA_HUMAN do not have phosphorylation site.

Dephosphorylation site
TGFA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295400V90MCOSMICProstate Cancer20668451

Differential expressed protein
TGFA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TGFA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TGFA_HUMANEGFR_HUMANligand -> receptorHPMR
TGFA_HUMANEGFR_HUMANotherKEGG
TBP_HUMANTGFA_HUMANTF -> target geneTRANSFAC
P53_HUMANTGFA_HUMANTF -> target geneTRANSFAC
SP1_HUMANTGFA_HUMANTF -> target geneTRANSFAC
ESR1_HUMANTGFA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04012ErbB signaling pathway
hsa05212Pancreatic cancer
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05223Non-small cell lung cancer
hsa05214Glioma
hsa05215Prostate cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060749mammary gland alveolus developmentIEAbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0048523negative regulation of cellular processIEAbiological_process
GO:0008083growth factor activityIDAmolecular_function
GO:0045840positive regulation of mitosisIDAbiological_process
GO:0000187activation of MAPK activityIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0001948glycoprotein bindingIEAmolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0001525angiogenesisIEAbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0005886plasma membraneNAScellular_component
GO:0045741positive regulation of epidermal growth factor-actIDAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIDAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0004708MAP kinase kinase activityIDAmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0042060wound healingIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005154epidermal growth factor receptor bindingIDAmolecular_function
GO:0000165MAPK cascadeIDAbiological_process


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