Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TF2B_HUMAN
Description:general transcription factor IIB [Source:HGNC Symbol;Acc:4648]
Location:chr1 p22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T123FKEITtMADRITFIIBPhosphoSitePlus
S76QNPLLsDGDLSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S70SRVGDsQNPLLPhosphoSitePlus
Y293SYRLIyPRAPDPhosphoSitePlus
S65ATKDPsRVGDSPhosphoSitePlus
T270SAEKRtQKEIGTFIIB; Sigma70_r4PhosphoSitePlus
T284GVADVtIRQSYTFIIB; Sigma70_r4PhosphoSitePlus

Dephosphorylation site
TF2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359531R132QHPIColorectal Cancer16959974
ENSP00000359531N139SCOSMICHead and Neck Cancer21798893
ENSP00000359531R137*COSMICOvarian Cancer21720365
ENSP00000359531R132QSjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
TF2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TF2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK4_HUMANTF2B_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANTF2B_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TF2B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0017025TBP-class protein bindingIEAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0046966thyroid hormone receptor bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0003677DNA bindingIEAmolecular_function


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