Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TAF1_HUMAN
Description:TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa [Source:HGNC Symbol;Acc:11535]
Location:chrX q13.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S526TSNSPsKESKKHPRD
S1152DDDTAsVTSLNPhosphoSitePlus
S1802NISYGsYEEPDPhosphoSitePlus
S1678VLDIPsATPEKPhosphoSitePlus
T1150HRDDDtASVTSHPRD
S524EATSNsPSKESPhosphoSitePlus; HPRD; phosphoELM
S1155TASVTsLNSSAPhosphoSitePlus; HPRD
Y364GSGFDyGFKLRPhosphoSitePlus
S1391SSILEsIINDMBromodomainPhosphoSitePlus
T1384TDPMVtLSSILPhosphoSitePlus
S1158VTSLNsSATGRPhosphoSitePlus
S545EATSNsPSKESHPRD
Y343VAEWRyGPARLPhosphoSitePlus
T542EKEEAtSNSPSHPRD
S1799EDSNIsYGSYEPhosphoSitePlus
T1154DTASVtSLNSSHPRD
T1643TPGPYtPQPPDPhosphoSitePlus
Y888EQCCAyYSMIADUF3591PhosphoSitePlus
T521EKEEAtSNSPSHPRD; phosphoELM
T442LPSSMtRNAMAPhosphoSitePlus
S1672DESNMsVLDIPPhosphoSitePlus
S1340EVRRKsLVLKFPhosphoSitePlus
S543KEEATsNSPSKHPRD
S1669VFQDEsNMSVLPhosphoSitePlus
Y350PARLWyDMLGVPhosphoSitePlus
S287VESEVsQKSLWPhosphoSitePlus
S137QPLCHsDYDEDPhosphoSitePlus
Y1366TVHCDyLNRPHPhosphoSitePlus
S1826GGYEVsEEEEDPhosphoSitePlus
Y889QCCAYySMIAADUF3591PhosphoSitePlus
S202ATQAEsEDGKLPhosphoSitePlus
S522KEEATsNSPSKHPRD
S547TSNSPsKESKKHPRD
S1138LLAAGsAASGNPhosphoSitePlus
S1633EAELEsLDPMTPhosphoSitePlus
T1175DTASVtSLNSSHPRD
T1379IHRRRtDPMVTPhosphoSitePlus
T198GPQEAtQAESEPhosphoSitePlus
T1701DIPSAtPEKQVHPRD
S1176TASVTsLNSSAHPRD
T1171HRDDDtASVTSHPRD
T1360KRRVGtTVHCDPhosphoSitePlus
T1680DIPSAtPEKQVPhosphoSitePlus; HPRD
Y1541FVPDYyKVIVNBromodomainPhosphoSitePlus

Dephosphorylation site
TAF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000389000N1513IBIOMARTBreast Cancer21930507, 21930502
ENSP00000362895E651KGreenman2007Skin Cancer17344846, 18428421
ENSP00000276072N1534IBIOMARTBreast Cancer21930507, 21930502
ENSP00000362895W1526LBIOMARTBreast Cancer21930507, 21930502
ENSP00000276072G709*BIOMARTBreast Cancer21930507, 21930502
ENSP00000389000S190YBIOMARTBreast Cancer21930507, 21930502
ENSP00000276072L479VTCGAOvarian Cancer21720365, 18772890
ENSP00000389000G688*BIOMARTBreast Cancer21930507, 21930502
ENSP00000362895G453DGreenman2007Intestines Cancer17344846, 18428421
ENSP00000362895S190YBIOMARTBreast Cancer21930507, 21930502
ENSP00000276072L458VTCGAOvarian Cancer21720365, 18772890
ENSP00000276072I1762VBIOMARTBrain Cancer21930507, 21930502
ENSP00000276072S211YBIOMARTBreast Cancer21930507, 21930502
ENSP00000276072W1547LBIOMARTBreast Cancer21930507, 21930502
ENSP00000389000W1526LBIOMARTBreast Cancer21930507, 21930502
ENSP00000362895G688*BIOMARTBreast Cancer21930507, 21930502
ENSP00000276072S1654TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000276072L1717RTCGAOvarian Cancer21720365, 18772890
ENSP00000276072G647DTCGAOvarian Cancer21720365, 18772890
ENSP00000276072L1738RTCGAOvarian Cancer21720365, 18772890
ENSP00000362895M691IGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000276072E1754DTCGAOvarian Cancer21720365, 18772890
ENSP00000362895N1513IBIOMARTBreast Cancer21930507, 21930502
ENSP00000276072G73ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000362895G453DHPIColorectal Cancer17344846

Differential expressed protein
TAF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TAF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TAF1_HUMANTF2AA_HUMANkinase -> substrateRegPhos
TAF1_HUMANP53_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03022Basal transcription factors

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010467gene expressionTASbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0000080G1 phase of mitotic cell cycleIGIbiological_process
GO:0000117regulation of transcription involved in G2/M-phaseISSbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0002039p53 bindingIPImolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0004402histone acetyltransferase activityIDAmolecular_function
GO:0006974response to DNA damage stimulusICbiological_process
GO:0017025TBP-class protein bindingIPImolecular_function
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016573histone acetylationIDAbiological_process
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0051123RNA polymerase II transcriptional preinitiation coISSbiological_process
GO:0044212transcription regulatory region DNA bindingISSmolecular_function
GO:0006352DNA-dependent transcription, initiationISSbiological_process
GO:0032436positive regulation of proteasomal ubiquitin-depenIDAbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0071339MLL1 complexIDAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0043565sequence-specific DNA bindingISSmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0060261positive regulation of transcription initiation frISSbiological_process
GO:0046777protein autophosphorylationTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005669transcription factor TFIID complexIDAcellular_component
GO:0070577histone acetyl-lysine bindingIDAmolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0016032viral reproductionTASbiological_process


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