UniProt/SwissProt ID: | TAF1_HUMAN |
Description: | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa [Source:HGNC Symbol;Acc:11535] |
Location: | chrX q13.1 |
Node attribute: | kinase |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S526 | TSNSPsKESKK | HPRD | |
S1152 | DDDTAsVTSLN | PhosphoSitePlus | |
S1802 | NISYGsYEEPD | PhosphoSitePlus | |
S1678 | VLDIPsATPEK | PhosphoSitePlus | |
T1150 | HRDDDtASVTS | HPRD | |
S524 | EATSNsPSKES | PhosphoSitePlus; HPRD; phosphoELM | |
S1155 | TASVTsLNSSA | PhosphoSitePlus; HPRD | |
Y364 | GSGFDyGFKLR | PhosphoSitePlus | |
S1391 | SSILEsIINDM | Bromodomain | PhosphoSitePlus |
T1384 | TDPMVtLSSIL | PhosphoSitePlus | |
S1158 | VTSLNsSATGR | PhosphoSitePlus | |
S545 | EATSNsPSKES | HPRD | |
Y343 | VAEWRyGPARL | PhosphoSitePlus | |
T542 | EKEEAtSNSPS | HPRD | |
S1799 | EDSNIsYGSYE | PhosphoSitePlus | |
T1154 | DTASVtSLNSS | HPRD | |
T1643 | TPGPYtPQPPD | PhosphoSitePlus | |
Y888 | EQCCAyYSMIA | DUF3591 | PhosphoSitePlus |
T521 | EKEEAtSNSPS | HPRD; phosphoELM | |
T442 | LPSSMtRNAMA | PhosphoSitePlus | |
S1672 | DESNMsVLDIP | PhosphoSitePlus | |
S1340 | EVRRKsLVLKF | PhosphoSitePlus | |
S543 | KEEATsNSPSK | HPRD | |
S1669 | VFQDEsNMSVL | PhosphoSitePlus | |
Y350 | PARLWyDMLGV | PhosphoSitePlus | |
S287 | VESEVsQKSLW | PhosphoSitePlus | |
S137 | QPLCHsDYDED | PhosphoSitePlus | |
Y1366 | TVHCDyLNRPH | PhosphoSitePlus | |
S1826 | GGYEVsEEEED | PhosphoSitePlus | |
Y889 | QCCAYySMIAA | DUF3591 | PhosphoSitePlus |
S202 | ATQAEsEDGKL | PhosphoSitePlus | |
S522 | KEEATsNSPSK | HPRD | |
S547 | TSNSPsKESKK | HPRD | |
S1138 | LLAAGsAASGN | PhosphoSitePlus | |
S1633 | EAELEsLDPMT | PhosphoSitePlus | |
T1175 | DTASVtSLNSS | HPRD | |
T1379 | IHRRRtDPMVT | PhosphoSitePlus | |
T198 | GPQEAtQAESE | PhosphoSitePlus | |
T1701 | DIPSAtPEKQV | HPRD | |
S1176 | TASVTsLNSSA | HPRD | |
T1171 | HRDDDtASVTS | HPRD | |
T1360 | KRRVGtTVHCD | PhosphoSitePlus | |
T1680 | DIPSAtPEKQV | PhosphoSitePlus; HPRD | |
Y1541 | FVPDYyKVIVN | Bromodomain | PhosphoSitePlus |
Dephosphorylation site |
TAF1_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000389000 | N1513I | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000362895 | E651K | Greenman2007 | Skin Cancer | 17344846, 18428421 |
ENSP00000276072 | N1534I | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000362895 | W1526L | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000276072 | G709* | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000389000 | S190Y | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000276072 | L479V | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000389000 | G688* | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000362895 | G453D | Greenman2007 | Intestines Cancer | 17344846, 18428421 |
ENSP00000362895 | S190Y | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000276072 | L458V | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000276072 | I1762V | BIOMART | Brain Cancer | 21930507, 21930502 |
ENSP00000276072 | S211Y | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000276072 | W1547L | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000389000 | W1526L | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000362895 | G688* | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000276072 | S1654T | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
ENSP00000276072 | L1717R | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000276072 | G647D | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000276072 | L1738R | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000362895 | M691I | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 |
ENSP00000276072 | E1754D | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000362895 | N1513I | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000276072 | G73E | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
ENSP00000362895 | G453D | HPI | Colorectal Cancer | 17344846 |
Differential expressed protein |
TAF1_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
TAF1_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
TAF1_HUMAN | TF2AA_HUMAN | kinase -> substrate | RegPhos |
TAF1_HUMAN | P53_HUMAN | kinase -> substrate | RegPhos |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa03022 | Basal transcription factors |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0010467 | gene expression | TAS | biological_process |
GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
GO:0018107 | peptidyl-threonine phosphorylation | IDA | biological_process |
GO:0000080 | G1 phase of mitotic cell cycle | IGI | biological_process |
GO:0000117 | regulation of transcription involved in G2/M-phase | ISS | biological_process |
GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
GO:0002039 | p53 binding | IPI | molecular_function |
GO:0008134 | transcription factor binding | IPI | molecular_function |
GO:0003713 | transcription coactivator activity | IDA | molecular_function |
GO:0004402 | histone acetyltransferase activity | IDA | molecular_function |
GO:0006974 | response to DNA damage stimulus | IC | biological_process |
GO:0017025 | TBP-class protein binding | IPI | molecular_function |
GO:0018105 | peptidyl-serine phosphorylation | IDA | biological_process |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0016573 | histone acetylation | IDA | biological_process |
GO:0006368 | transcription elongation from RNA polymerase II pr | TAS | biological_process |
GO:0051123 | RNA polymerase II transcriptional preinitiation co | ISS | biological_process |
GO:0044212 | transcription regulatory region DNA binding | ISS | molecular_function |
GO:0006352 | DNA-dependent transcription, initiation | ISS | biological_process |
GO:0032436 | positive regulation of proteasomal ubiquitin-depen | IDA | biological_process |
GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
GO:0005654 | nucleoplasm | TAS | cellular_component |
GO:0003677 | DNA binding | IEA | molecular_function |
GO:0071339 | MLL1 complex | IDA | cellular_component |
GO:0019048 | virus-host interaction | IEA | biological_process |
GO:0043565 | sequence-specific DNA binding | ISS | molecular_function |
GO:0005524 | ATP binding | IEA | molecular_function |
GO:0060261 | positive regulation of transcription initiation fr | ISS | biological_process |
GO:0046777 | protein autophosphorylation | TAS | biological_process |
GO:0005634 | nucleus | IDA | cellular_component |
GO:0005669 | transcription factor TFIID complex | IDA | cellular_component |
GO:0070577 | histone acetyl-lysine binding | IDA | molecular_function |
GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
GO:0016032 | viral reproduction | TAS | biological_process |