| UniProt/SwissProt ID: | SYCP2_HUMAN |
| Description: | synaptonemal complex protein 2 [Source:HGNC Symbol;Acc:11490] |
| Location: | chr20 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1241 | HINENyIQSKR | PhosphoSitePlus | |
| Y1140 | KSISPyPKTSS | PhosphoSitePlus | |
| S1040 | CEQEFsHSFKE | PhosphoSitePlus | |
| S1138 | ITKSIsPYPKT | PhosphoSitePlus | |
| T1019 | LPRKAtKTKKN | PhosphoSitePlus | |
| S543 | SLKSRsSEGRH | PhosphoSitePlus | |
| S1111 | SGSPSsIEVTR | PhosphoSitePlus | |
| Y1130 | DFTQDyDCITK | PhosphoSitePlus | |
| S544 | LKSRSsEGRHR | PhosphoSitePlus | |
| S436 | GEELVsLKEKS | PhosphoSitePlus | |
| T470 | SQLEKtTPSKR | HPRD; SysPTM | |
| T471 | QLEKTtPSKRK | PhosphoSitePlus | |
| T1021 | RKATKtKKNYK | PhosphoSitePlus | |
| T501 | VLFSNtSIPPR | PhosphoSitePlus | |
| S1110 | LSGSPsSIEVT | PhosphoSitePlus | |
| S478 | SKRKMsEASMI | PhosphoSitePlus | |
| T1060 | HSRMKtVKLPK | PhosphoSitePlus | |
| S1056 | EENIHsRMKTV | PhosphoSitePlus | |
| S1042 | QEFSHsFKENI | PhosphoSitePlus | |
| S1523 | MSVFMsHERNA | PhosphoSitePlus | |
| Dephosphorylation site |
| SYCP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000350162 | K474N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000350162 | R542T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350162 | N193I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000360040 | R542T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350162 | K1427* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350162 | S1234C | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000360040 | R509K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000360040 | S1234C | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350162 | K1315R | COSMIC | Lung Cancer | 20668451 | ENSP00000350162 | S1161L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350162 | R509K | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000360040 | Gastric Cancer | Treatment (none vs. 5-fluorouracil treatment) | cell line | Up | 8.8 | 16900703 | ENSP00000360040 | Uterine Cancer | Treatment(none vs. transfected with the pOP13 vector that containing E7) | cell line | Up | 14997504 |
| Hyperphosphorylation site |
| SYCP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ANPRB_HUMAN | SYCP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SYCP2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000800 | lateral element | IEA | cellular_component |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0007130 | synaptonemal complex assembly | NAS | biological_process |
| GO:0009887 | organ morphogenesis | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0048808 | male genitalia morphogenesis | IEA | biological_process |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0007140 | male meiosis | IEA | biological_process |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0007128 | meiotic prophase I | NAS | biological_process |
| GO:0007143 | female meiosis | IEA | biological_process |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0000795 | synaptonemal complex | IEA | cellular_component |
| GO:0000795 | synaptonemal complex | NAS | cellular_component |
| GO:0009566 | fertilization | IEA | biological_process |