| UniProt/SwissProt ID: | STAM2_HUMAN |
| Description: | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [Source:HGNC Symbol;Acc:11358] |
| Location: | chr2 q23.3 |
| Node attribute: | substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S161 | KNGTSsNKNKE | PhosphoSitePlus | |
| Y371 | NEAPVySVYSK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Y374 | PVYSVySKLHP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S375 | VYSVYsKLHPP | PhosphoSitePlus | |
| S372 | EAPVYsVYSKL | PhosphoSitePlus; HPRD; RegPhos | |
| Y290 | SEPEPvYIDED | HPRD | |
| Y192 | ETKSLyPSSEI | EGFR | HPRD; RegPhos; SysPTM |
| S160 | AKNGTsSNKNK | PhosphoSitePlus | |
| T159 | AAKNGtSSNKN | PhosphoSitePlus | |
| Y191 | TETKSlYPSSE | HPRD | |
| Y291 | EPEPVyIDEDK | PhosphoSitePlus; HPRD; SysPTM | |
| Y192 | ETKSLyPSSEI | PhosphoSitePlus; phosphoELM; RegPhos; SysPTM | |
| Dephosphorylation site |
| STAM2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263904 | D334A | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| STAM2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| STAM2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | STAM2_HUMAN | kinase -> substrate | RegPhos |
| EGFR_HUMAN | STAM2_HUMAN | kinase -> substrate | HPRD; RegPhos |
| JAK1_HUMAN | STAM2_HUMAN | kinase -> substrate | NetPath |
| STAM2_HUMAN | JAK1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042059 | negative regulation of epidermal growth factor rec | TAS | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0031901 | early endosome membrane | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016197 | endosomal transport | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0016044 | cellular membrane organization | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |