Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRSF6_HUMAN
Description:serine/arginine-rich splicing factor 6 [Source:HGNC Symbol;Acc:10788]
Location:chr20 q13.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S196YSGSRsRSRSRPhosphoSitePlus
S295KSKSRsRSQSRPhosphoSitePlus; HPRD
S265HSRSRsKDEYEPhosphoSitePlus; HPRD
Y53ADDAVyELNGKRRM_1PhosphoSitePlus
S253KSKPKsDRGSHPhosphoSitePlus
T323PPKRAtSRSRSHPRD
S324PKRATsRSRSRHPRD
Y191SHRRSySGSRSPhosphoSitePlus
S301RSQSRsNSPLPPhosphoSitePlus; HPRD; phosphoELM
S257KSDRGsHSHSRPhosphoSitePlus; HPRD
S316KARSVsPPPKRPhosphoSitePlus; HPRD; phosphoELM
S122LSSRCsWQDLKRRM_1PhosphoSitePlus
S314PSKARsVSPPPPhosphoSitePlus; HPRD; phosphoELM
S293DIKSKsRSRSQPhosphoSitePlus
S190TSHRRsYSGSRPhosphoSitePlus
S45VEFEDsRDADDHPRD; phosphoELM
S45VEFEDsRDADDRRM_1PhosphoSitePlus
S297KSRSRsQSRSNPhosphoSitePlus; HPRD; phosphoELM
S194RSYSGsRSRSRPhosphoSitePlus
S259DRGSHsHSRSRPhosphoSitePlus; HPRD; phosphoELM
S326RATSRsRSRSRPhosphoSitePlus; HPRD
Y80RDRDGySYGSRPhosphoSitePlus
S119VENLSsRCSWQHPRD
S310LPVPPsKARSVPhosphoSitePlus
T146AHKERtNEGVIRRM_1PhosphoSitePlus
S84GYSYGsRSGGGPhosphoSitePlus
S299RSRSQsRSNSPPhosphoSitePlus; HPRD; phosphoELM
S263HSHSRsRSKDEHPRD
S118IVENLsSRCSWHPRD
S86SYGSRsGGGGYPhosphoSitePlus
S118IVENLsSRCSWRRM_1PhosphoSitePlus
Y138AGEVTyADAHKRRM_1PhosphoSitePlus
Y91SGGGGySSRRTPhosphoSitePlus
S303QSRSNsPLPVPPhosphoSitePlus; HPRD; phosphoELM
S291KGDIKsKSRSRPhosphoSitePlus
S81DRDGYsYGSRSPhosphoSitePlus; HPRD
Y82RDGYSyGSRSGPhosphoSitePlus
S97SSRRTsGRDKYPhosphoSitePlus
S119VENLSsRCSWQRRM_1PhosphoSitePlus
S261GSHSHsRSRSKHPRD
S192HRRSYsGSRSRPhosphoSitePlus

Dephosphorylation site
SRSF6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000244020R145QSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000244020S236PCOSMICHead and Neck Cancer21984974
ENSP00000244020R321KCOSMICHead and Neck Cancer21798893
ENSP00000244020R145QHPIColorectal Cancer16959974

Differential expressed protein
SRSF6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SRSF6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK1_HUMANSRSF6_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SRSF6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006369termination of RNA polymerase II transcriptionTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0006376mRNA splice site selectionTASbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0048025negative regulation of mRNA splicing, via spliceosIDAbiological_process
GO:0031124mRNA 3'-end processingTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0000398mRNA splicing, via spliceosomeTASbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0006406mRNA export from nucleusTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23