Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SPRE1_HUMAN
Description:sprouty-related, EVH1 domain containing 1 [Source:HGNC Symbol;Acc:20249]
Location:chr15 q14
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S8EETATsDNDNSHPRD
Y337RSRCVyCQERFSproutyPhosphoSitePlus
Y211SRSMEyVQRQIPhosphoSitePlus
Y168VTSEPyRSSNIPhosphoSitePlus
Y292SKKSDyLYSCGPhosphoSitePlus
T5_MSEEtATSDNPhosphoSitePlus
Y294KSDYLySCGDEPhosphoSitePlus
S238SIRHVsFQDEDPhosphoSitePlus; HPRD
Y82KKDLIyNKVTPWH1PhosphoSitePlus
T7DNDNHPRD
T5TSDNHPRD
S2____MsEETATPhosphoSitePlus

Dephosphorylation site
SPRE1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000299084D274ATCGAOvarian Cancer21720365, 18772890
ENSP00000299084R273ICOSMICLung Cancer20668451
ENSP00000299084E328*COSMICLung Cancer20668451
ENSP00000299084S27*COSMICHead and Neck Cancer21798893
ENSP00000299084D274ACOSMICOvarian Cancer21720365
ENSP00000299084Q50*COSMICMelanoma21499247

Differential expressed protein
SPRE1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SPRE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KIT_HUMANSPRE1_HUMANkinase -> substrateNetPath
SOS1_HUMANSPRE1_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009966regulation of signal transductionIEAbiological_process
GO:0010923negative regulation of phosphatase activityIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0043517positive regulation of DNA damage response, signalIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0019901protein kinase bindingIEAmolecular_function
GO:0090311regulation of protein deacetylationIEAbiological_process
GO:0005173stem cell factor receptor bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0010801negative regulation of peptidyl-threonine phosphorIEAbiological_process
GO:0000188inactivation of MAPK activityIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005901caveolaIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0019902phosphatase bindingIDAmolecular_function
GO:0030291protein serine/threonine kinase inhibitor activityIEAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process


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