| UniProt/SwissProt ID: | SPB5_HUMAN |
| Description: | serpin peptidase inhibitor, clade B (ovalbumin), member 5 [Source:HGNC Symbol;Acc:8949] |
| Location: | chr18 q21.33 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S298 | LKHIFsEDTSD | Serpin | PhosphoSitePlus |
| T50 | GAKGDtANEIG | Serpin | PhosphoSitePlus |
| S240 | DVEDEsTGLEK | Serpin | PhosphoSitePlus |
| S9 | LQLANsAFAVD | HPRD | |
| T310 | SGMSEtKGVAL | Serpin | PhosphoSitePlus |
| S97 | LYVDKsLNLST | Serpin | PhosphoSitePlus |
| S107 | TEFISsTKRPY | HPRD | |
| Y356 | DHPFIyIIRHN | HPRD | |
| S135 | GQINNsIKDLT | Serpin | PhosphoSitePlus |
| T157 | SVNDQtKILVV | Serpin | PhosphoSitePlus |
| Y356 | DHPFIyIIRHN | Serpin | PhosphoSitePlus |
| S106 | STEFIsSTKRP | HPRD | |
| S135 | GQINNsIKDLT | HPRD | |
| T102 | SLNLStEFISS | HPRD | |
| S9 | LQLANsAFAVD | Serpin | PhosphoSitePlus |
| T108 | EFISStKRPYA | HPRD | |
| T118 | AKELEtVDFKD | Serpin | PhosphoSitePlus |
| S316 | KGVALsNVIHK | Serpin | PhosphoSitePlus |
| Dephosphorylation site |
| SPB5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000372221 | M307L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000372221 | M307L | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000372221 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 17902640 | ENSP00000372221 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.17 | 16470630 | ENSP00000372221 | Hepatocellular Carcinoma | Treatment (none vs resveratrol-treatment) | cell line | Down | 19996131 | ENSP00000372221 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Down | 0.4 | 20804217 | ENSP00000372221 | Breast Cancer | Normal vs. Cancer | tissue | Up | 3.4 | 20005186 | ENSP00000372221 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.06 | 20052998 | ENSP00000372221 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.046 | 20052998 | ENSP00000372221 | Breast Cancer | Metastasis | cell line | Down | 0.8 | 20052998 | ENSP00000372221 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.093 | 20052998 | ENSP00000372221 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.09 | 20052998 | ENSP00000372221 | Breast Cancer | Metastasis | cell line | Down | 0.98 | 20052998 | ENSP00000372221 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.78 | 20739354 | ENSP00000372221 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.78 | 20739354 | ENSP00000372221 | Oral Cancer | Normal vs. Cancer | tissue | Up | 5.3 | 19691830 | ENSP00000372221 | Gastric Cancer | Normal vs. Cancer | cell line | Up | 6.9 | 20812763 | ENSP00000372221 | Gastric Cancer | Normal vs. Cancer | cell line | Up | 4.9 | 20812763 | ENSP00000372221 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 2.4 | 19199705 |
| Hyperphosphorylation site |
| SPB5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | SPB5_HUMAN | TF -> target gene | KEGG |
| P53_HUMAN | SPB5_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04115 | p53 signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0030198 | extracellular matrix organization | IEA | biological_process |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0050678 | regulation of epithelial cell proliferation | IEA | biological_process |
| GO:0030162 | regulation of proteolysis | IBA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010951 | negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0060512 | prostate gland morphogenesis | IEA | biological_process |
| GO:0002009 | morphogenesis of an epithelium | IEA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |