Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SPB5_HUMAN
Description:serpin peptidase inhibitor, clade B (ovalbumin), member 5 [Source:HGNC Symbol;Acc:8949]
Location:chr18 q21.33
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S298LKHIFsEDTSDSerpinPhosphoSitePlus
T50GAKGDtANEIGSerpinPhosphoSitePlus
S240DVEDEsTGLEKSerpinPhosphoSitePlus
S9LQLANsAFAVDHPRD
T310SGMSEtKGVALSerpinPhosphoSitePlus
S97LYVDKsLNLSTSerpinPhosphoSitePlus
S107TEFISsTKRPYHPRD
Y356DHPFIyIIRHNHPRD
S135GQINNsIKDLTSerpinPhosphoSitePlus
T157SVNDQtKILVVSerpinPhosphoSitePlus
Y356DHPFIyIIRHNSerpinPhosphoSitePlus
S106STEFIsSTKRPHPRD
S135GQINNsIKDLTHPRD
T102SLNLStEFISSHPRD
S9LQLANsAFAVDSerpinPhosphoSitePlus
T108EFISStKRPYAHPRD
T118AKELEtVDFKDSerpinPhosphoSitePlus
S316KGVALsNVIHKSerpinPhosphoSitePlus

Dephosphorylation site
SPB5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000372221M307LTCGAOvarian Cancer21720365, 18772890
ENSP00000372221M307LCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000372221Uterine CancerNormal vs. CancertissueDown17902640
ENSP00000372221Breast CancerNormal vs. CancertissueDown0.1716470630
ENSP00000372221Hepatocellular CarcinomaTreatment (none vs resveratrol-treatment)cell lineDown19996131
ENSP00000372221Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.420804217
ENSP00000372221Breast CancerNormal vs. CancertissueUp3.420005186
ENSP00000372221Breast CancerNormal vs. Cancercell lineDown0.0620052998
ENSP00000372221Breast CancerNormal vs. Cancercell lineDown0.04620052998
ENSP00000372221Breast CancerMetastasiscell lineDown0.820052998
ENSP00000372221Breast CancerNormal vs. Cancercell lineDown0.09320052998
ENSP00000372221Breast CancerNormal vs. Cancercell lineDown0.0920052998
ENSP00000372221Breast CancerMetastasiscell lineDown0.9820052998
ENSP00000372221Breast CancerNormal vs. CancertissueDown0.7820739354
ENSP00000372221Breast CancerNormal vs. CancertissueDown0.7820739354
ENSP00000372221Oral CancerNormal vs. CancertissueUp5.319691830
ENSP00000372221Gastric CancerNormal vs. Cancercell lineUp6.920812763
ENSP00000372221Gastric CancerNormal vs. Cancercell lineUp4.920812763
ENSP00000372221Pancreatic CancerNormal vs. CancertissueUp2.419199705

Hyperphosphorylation site
SPB5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P53_HUMANSPB5_HUMANTF -> target geneKEGG
P53_HUMANSPB5_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0030162regulation of proteolysisIBAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010951negative regulation of endopeptidase activityIBAbiological_process
GO:0060512prostate gland morphogenesisIEAbiological_process
GO:0002009morphogenesis of an epitheliumIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component


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