| UniProt/SwissProt ID: | SP2_HUMAN |
| Description: | Sp2 transcription factor [Source:HGNC Symbol;Acc:11207] |
| Location: | chr17 q21.32 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T192 | SSTTTtPVQSG | HPRD | |
| S78 | APLPLsPGKNS | PhosphoSitePlus; HPRD; phosphoELM | |
| T383 | ATSNTtCSSPA | PhosphoSitePlus | |
| S380 | TAAATsNTTCS | PhosphoSitePlus | |
| T535 | PDCGKtFRKTS | zf-C2H2 | PhosphoSitePlus |
| S389 | CSSPAsRAPHL | PhosphoSitePlus | |
| S83 | SPGKNsFGILS | PhosphoSitePlus | |
| S395 | RAPHLsGTSKK | PhosphoSitePlus | |
| T550 | HVRLHtGERPF | PhosphoSitePlus; HPRD; phosphoELM | |
| S569 | KRFTRsDELQR | zf-C2H2 | PhosphoSitePlus |
| T63 | APPQPtPRKLV | PhosphoSitePlus | |
| Dephosphorylation site |
| SP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365931 | A418V | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| SP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP2_HUMAN | CCND1_HUMAN | TF -> target gene | TRANSFAC |
| SP2_HUMAN | NOS1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SP2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006955 | immune response | TAS | biological_process |
| GO:0042826 | histone deacetylase binding | IPI | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |