Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOST_HUMAN
Description:sclerostin [Source:HGNC Symbol;Acc:13771]
Location:chr17 q21.31
Node attribute:ligand

Phosphorylation site
SOST_HUMAN do not have phosphorylation site.

Dephosphorylation site
SOST_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000301691*214YCOSMICOvarian Cancer21720365
ENSP00000301691*214CCOSMICNeoplasms by Histologic Type12673678

Differential expressed protein
SOST_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SOST_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SOST_HUMANLRP5_HUMANligand -> receptorHPMR
SOST_HUMANLRP6_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
SOST_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005615extracellular spaceIEAcellular_component
GO:0071374cellular response to parathyroid hormone stimulusIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0008201heparin bindingIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIDAbiological_process
GO:0030514negative regulation of BMP signaling pathwayIDAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0030279negative regulation of ossificationNASbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0009612response to mechanical stimulusIEPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0031333negative regulation of protein complex assemblyIDAbiological_process
GO:2000054negative regulation of Wnt receptor signaling pathIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001503ossificationIEAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0008134transcription factor bindingIDAmolecular_function