| UniProt/SwissProt ID: | SOAT1_HUMAN |
| Description: | sterol O-acyltransferase 1 [Source:HGNC Symbol;Acc:11177] |
| Location: | chr1 q25.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S16 | NRLSKsRENPE | PhosphoSitePlus | |
| S8 | GEEKMsLRNRL | PhosphoSitePlus | |
| S14 | LRNRLsKSREN | PhosphoSitePlus | |
| S71 | MKEVGsHFDDF | PhosphoSitePlus | |
| Dephosphorylation site |
| SOAT1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356591 | R27K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000356591 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 | |
| Hyperphosphorylation site |
| SOAT1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | SOAT1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SOAT1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0010742 | macrophage derived foam cell differentiation | IMP | biological_process |
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0004772 | sterol O-acyltransferase activity | IEA | molecular_function |
| GO:0015485 | cholesterol binding | IDA | molecular_function |
| GO:0034736 | cholesterol O-acyltransferase activity | IDA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005789 | endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0008203 | cholesterol metabolic process | IEA | biological_process |
| GO:0034435 | cholesterol esterification | IDA | biological_process |
| GO:0042986 | positive regulation of amyloid precursor protein b | IMP | biological_process |
| GO:0034379 | very-low-density lipoprotein particle assembly | IMP | biological_process |
| GO:0000062 | fatty-acyl-CoA binding | IDA | molecular_function |
| GO:0042632 | cholesterol homeostasis | TAS | biological_process |
| GO:0033344 | cholesterol efflux | IMP | biological_process |
| GO:0010878 | cholesterol storage | IMP | biological_process |