Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SND1_HUMAN
Description:staphylococcal nuclease and tudor domain containing 1 [Source:HGNC Symbol;Acc:30646]
Location:chr7 q32.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T418KKVNVtVDYIRSNasePhosphoSitePlus
Y661KVWAHyEEQPVPhosphoSitePlus
Y895LNLWRyGDFRAPhosphoSitePlus
S538YVFSGsRLKLYPhosphoSitePlus
T98KEVCFtIENKTSNasePhosphoSitePlus
Y109PQGREyGMIYLHPRD; phosphoELM
S29IKMVLsGCAIIPhosphoSitePlus
S781RLGTLsPAFSTHPRD; phosphoELM; SysPTM
S3___MAsSAQSGPhosphoSitePlus; SysPTM
Y728PVEGSyAPRRGTUDORPhosphoSitePlus
S3AQSGHPRD; SysPTM
S527QRAGRsEAVVEPhosphoSitePlus
S426YIRPAsPATETHPRD; phosphoELM
Y908ADEFGyHPRD; phosphoELM
S909DEFGYsR____PhosphoSitePlus
S10AQSGGsSGGPAHPRD
T383LEGENtQDKNKSNasePhosphoSitePlus
T240ADGSEtPEPFASNasePhosphoSitePlus; SysPTM
T240ADGSEtPEPFAHPRD; phosphoELM; SysPTM
Y113EYGMIyLGKDTSNasePhosphoSitePlus
S642SSYYKsLLSAESNasePhosphoSitePlus
T103TIENKtPQGREHPRD
T418KKVNVtVDYIRHPRD
S372TIHLSsIRPPRSNasePhosphoSitePlus
Y109PQGREyGMIYLSNasePhosphoSitePlus
S536VEYVFsGSRLKPhosphoSitePlus
T333DYVAPtANLDQPhosphoSitePlus
Y421NVTVDyIRPASSNasePhosphoSitePlus
Y476QRSSHyDELLASNasePhosphoSitePlus
S426YIRPAsPATETSNasePhosphoSitePlus
Y878KVITEyLNAQESNasePhosphoSitePlus
T429PASPAtETVPAHPRD; phosphoELM; SysPTM
S238READGsETPEPSNasePhosphoSitePlus; SysPTM
S371KTIHLsSIRPPSNasePhosphoSitePlus
Y329RIWRDyVAPTAPhosphoSitePlus
S238READGsETPEPHPRD; SysPTM
T103TIENKtPQGRESNasePhosphoSitePlus
Y533EAVVEyVFSGSPhosphoSitePlus
Y908ADEFGySR___PhosphoSitePlus
T431SPATEtVPAFSSNasePhosphoSitePlus
S781RLGTLsPAFSTTUDORPhosphoSitePlus; SysPTM
S727PPVEGsYAPRRTUDORPhosphoSitePlus

Dephosphorylation site
SND1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000346762D468ECOSMICOvarian Cancer21720365
ENSP00000346762R174WBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000346762follicular thyroid carcinomaNormal vs. CancertissueDown0.7818316623
ENSP00000346762Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000346762Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.4219422301

Hyperphosphorylation site
SND1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BMX_HUMANSND1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSND1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SND1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0016442RNA-induced silencing complexIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0042470melanosomeIEAcellular_component
GO:0031047gene silencing by RNAIEAbiological_process
GO:0016788hydrolase activity, acting on ester bondsIEAmolecular_function
GO:0003712transcription cofactor activityTASmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0004518nuclease activityIEAmolecular_function


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