Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMUF2_HUMAN
Description:SMAD specific E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:16809]
Location:chr17 q24.1
Node attribute:ubiquitination(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T168WEERRtASGRIWWPhosphoSitePlus
Y434EEGLDyGGVARPhosphoSitePlus
S170ERRTAsGRIQYWWPhosphoSitePlus
Y499VFHGHyIDGGFHECTPhosphoSitePlus
S406EIFEEsYRQVMPhosphoSitePlus
Y407IFEESyRQVMKPhosphoSitePlus
S203PGRPLsCFVDEPhosphoSitePlus

Dephosphorylation site
SMUF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262435L100FCOSMICMelanoma21499247
ENSP00000262435R408*COSMICMelanoma21499247
ENSP00000262435K654IBIOMARTBreast Cancer21930507, 21930502
ENSP00000262435R592*COSMICLung Cancer
ENSP00000262435L529FCOSMICMelanoma21499247

Differential expressed protein
SMUF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SMUF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SMUF2_HUMANID1_HUMANubiquitinationNetPath
SMUF2_HUMANID3_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis
hsa04144Endocytosis
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005654nucleoplasmTAScellular_component
GO:0030579ubiquitin-dependent SMAD protein catabolic processIDAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0005737cytoplasmIBAcellular_component
GO:0046332SMAD bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenNASbiological_process
GO:0030509BMP signaling pathwayTASbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0000151ubiquitin ligase complexIDAcellular_component
GO:0005634nucleusIBAcellular_component
GO:0007179transforming growth factor beta receptor signalingIBAbiological_process
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0006464cellular protein modification processIEAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0042787protein ubiquitination involved in ubiquitin-depenIBAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0046332SMAD bindingIEAmolecular_function
GO:0005160transforming growth factor beta receptor bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0017015regulation of transforming growth factor beta receNASbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process


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