| UniProt/SwissProt ID: | SMBT1_HUMAN |
| Description: | Scm-like with four mbt domains 1 [Source:HGNC Symbol;Acc:20255] |
| Location: | chr3 p21.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S738 | EKKSCsSSPTQ | PhosphoSitePlus | |
| S791 | RLHLDsNPLKW | PhosphoSitePlus | |
| T592 | VEIVKtADRVT | DUF3588 | PhosphoSitePlus |
| S765 | ELRTFsFSDDE | PhosphoSitePlus; HPRD; phosphoELM | |
| T452 | GHPLStPRRAR | MBT | PhosphoSitePlus |
| T116 | EQNKKtLEAPE | MBT | PhosphoSitePlus |
| Y639 | KYTHYyGKKKN | PhosphoSitePlus | |
| S775 | ENKPPsPKEIR | PhosphoSitePlus; HPRD; phosphoELM | |
| S744 | SSPTQsEISTS | PhosphoSitePlus | |
| S749 | SEISTsLPPDR | PhosphoSitePlus | |
| S451 | NGHPLsTPRRA | MBT | PhosphoSitePlus |
| T407 | CVATItAVRGS | MBT | PhosphoSitePlus |
| T763 | KRELRtFSFSD | PhosphoSitePlus; HPRD | |
| S767 | RTFSFsDDENK | PhosphoSitePlus; HPRD; phosphoELM | |
| Y361 | FDWADyLKQCG | PhosphoSitePlus | |
| T445 | LGWCEtNGHPL | MBT | PhosphoSitePlus |
| S553 | AAYKPsRVLRE | DUF3588 | PhosphoSitePlus |
| Y105 | RKADLyPIGWC | MBT | PhosphoSitePlus |
| Dephosphorylation site |
| SMBT1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000378235 | S412Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000350789 | S412Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000378233 | E821K | COSMIC | Skin Cancer | 21984974 | ENSP00000296295 | S412Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000378233 | S412Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SMBT1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SMBT1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYRK3_HUMAN | SMBT1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK4_HUMAN | SMBT1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SMBT1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |