| UniProt/SwissProt ID: | SIG10_HUMAN |
| Description: | sialic acid binding Ig-like lectin 10 [Source:HGNC Symbol;Acc:15620] |
| Location: | chr19 q13.41 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y667 | QEELHyATLNF | JAK3 | phosphoELM; RegPhos |
| S298 | RVLSSsHPWGP | HPRD | |
| Y597 | STILDyINVVP | PhosphoSitePlus | |
| S331 | ENRLGsQQRAL | Ig_2 | PhosphoSitePlus |
| Y597 | STILDyINVVP | JAK3 | phosphoELM; RegPhos |
| Y667 | QEELHyATLNF | Lck | phosphoELM; RegPhos |
| Y597 | STILDyINVVP | Lck | phosphoELM; RegPhos |
| Y691 | GTQADyAEVKF | Lck | RegPhos |
| S592 | RFSRHsTILDY | PhosphoSitePlus | |
| Y691 | GTQADyAEVK | JAK3 | phosphoELM |
| T250 | ISRDNtPALEP | PhosphoSitePlus | |
| S9 | PLLLSsLLGGS | PhosphoSitePlus | |
| Y691 | GTQADyAEVKF | PhosphoSitePlus | |
| Y691 | GTQADyAEVK | Lck | phosphoELM |
| Y691 | GTQADyAEVKF | JAK3 | RegPhos |
| S8 | LPLLLsSLLGG | PhosphoSitePlus | |
| T322 | DSGRYtCRAEN | Ig_2 | PhosphoSitePlus |
| Y667 | QEELHyATLNF | ITK | phosphoELM; RegPhos |
| S589 | PRPRFsRHSTI | PhosphoSitePlus | |
| S339 | RALDLsVQYPP | Ig_2 | PhosphoSitePlus |
| Y667 | QEELHyATLNF | PhosphoSitePlus; RegPhos | |
| Y57 | GSTPAyGYWFK | V-set | PhosphoSitePlus |
| T593 | FSRHStILDYI | PhosphoSitePlus | |
| Y597 | STILDyINVVP | ITK | phosphoELM; RegPhos |
| S38 | EGLCIsVPCSF | V-set | PhosphoSitePlus |
| Dephosphorylation site |
| SIG10_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000345243 | S402F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000345243 | F548V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000389132 | F490V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000345243 | R47Q | COSMIC | Melanoma | 21499247 | ENSP00000389132 | R47Q | COSMIC | Melanoma | 21499247 | ENSP00000389132 | L566F | COSMIC | Skin Cancer | 21984974 | ENSP00000389132 | S344F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000345243 | L624F | COSMIC | Skin Cancer | 21984974 | ENSP00000345243 | S402Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000389132 | S344Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000408387 | S344F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000342389 | S402F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SIG10_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SIG10_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LCK_HUMAN | SIG10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | SIG10_HUMAN | kinase -> substrate | RegPhos |
| ITK_HUMAN | SIG10_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| JAK3_HUMAN | SIG10_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| SIG10_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |