| UniProt/SwissProt ID: | SH2B3_HUMAN |
| Description: | SH2B adaptor protein 3 [Source:HGNC Symbol;Acc:29605] |
| Location: | chr12 q24.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S553 | NRARDsDYEMD | PhosphoSitePlus | |
| S16 | PSSAPsASPAA | PhosphoSitePlus | |
| Y572 | AIDNQyTPL__ | PhosphoSitePlus | |
| S559 | DYEMDsSSRSH | PhosphoSitePlus | |
| S18 | SAPSAsPAAAP | PhosphoSitePlus | |
| S10 | ALQPSsPSSAP | PhosphoSitePlus | |
| Y273 | MPDNLyTFVLK | LCK | HPRD; RegPhos |
| S150 | IFRRRsAGELP | PhosphoSitePlus; HPRD | |
| Y273 | MPDNLyTFVLK | ZAP70 | HPRD; phosphoELM; RegPhos |
| T159 | LPAAHtAAAPG | PhosphoSitePlus | |
| Y203 | EAVLRySLADE | PhosphoSitePlus | |
| Y555 | ARDSDyEMDSS | PhosphoSitePlus | |
| S560 | YEMDSsSRSHL | PhosphoSitePlus | |
| Y273 | MPDNLyTFVLK | Lck | phosphoELM; RegPhos |
| Y273 | MPDNLyTFVLK | PH | PhosphoSitePlus |
| Dephosphorylation site |
| SH2B3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000345492 | S360C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000345492 | S360C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| SH2B3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SH2B3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAP70_HUMAN | SH2B3_HUMAN | kinase -> substrate | HPRD; RegPhos; NetPath; Robert H Newman (2013) |
| LCK_HUMAN | SH2B3_HUMAN | kinase -> substrate | HPRD; RegPhos; NetPath; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04722 | Neurotrophin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032403 | protein complex binding | IEA | molecular_function |
| GO:0030097 | hemopoiesis | IEA | biological_process |
| GO:0035162 | embryonic hemopoiesis | IEA | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0042301 | phosphate ion binding | IEA | molecular_function |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |