Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SH2B3_HUMAN
Description:SH2B adaptor protein 3 [Source:HGNC Symbol;Acc:29605]
Location:chr12 q24.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S553NRARDsDYEMDPhosphoSitePlus
S16PSSAPsASPAAPhosphoSitePlus
Y572AIDNQyTPL__PhosphoSitePlus
S559DYEMDsSSRSHPhosphoSitePlus
S18SAPSAsPAAAPPhosphoSitePlus
S10ALQPSsPSSAPPhosphoSitePlus
Y273MPDNLyTFVLKLCKHPRD; RegPhos
S150IFRRRsAGELPPhosphoSitePlus; HPRD
Y273MPDNLyTFVLKZAP70HPRD; phosphoELM; RegPhos
T159LPAAHtAAAPGPhosphoSitePlus
Y203EAVLRySLADEPhosphoSitePlus
Y555ARDSDyEMDSSPhosphoSitePlus
S560YEMDSsSRSHLPhosphoSitePlus
Y273MPDNLyTFVLKLckphosphoELM; RegPhos
Y273MPDNLyTFVLKPHPhosphoSitePlus

Dephosphorylation site
SH2B3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000345492S360CTCGAOvarian Cancer21720365, 18772890
ENSP00000345492S360CCOSMICOvarian Cancer21720365

Differential expressed protein
SH2B3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SH2B3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAP70_HUMANSH2B3_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
LCK_HUMANSH2B3_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032403protein complex bindingIEAmolecular_function
GO:0030097hemopoiesisIEAbiological_process
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0042301phosphate ion bindingIEAmolecular_function
GO:0004871signal transducer activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process


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