Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SETB1_HUMAN
Description:SET domain, bifurcated 1 [Source:HGNC Symbol;Acc:10761]
Location:chr1 q21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T338IEEYVtAYPNRPhosphoSitePlus
Y678YKPFYyILDITPhosphoSitePlus
Y677PYKPFyYILDIPhosphoSitePlus
T507GHSSPtSPALSPhosphoSitePlus
S1163QVAVKsTRGFASETPhosphoSitePlus
S1108SSSTEsEGESGSETPhosphoSitePlus
T1197PVRKNtRQFYDSETPhosphoSitePlus
S504VGSGHsSPTSPPhosphoSitePlus
S1138IQTISsGSEGDSETPhosphoSitePlus
S1104VLTLSsSTESESETPhosphoSitePlus
S905ESNDDsSDDNFSETPhosphoSitePlus
T1180IAIKStNMASVHPRD; phosphoELM
S111QYRDSsSEDESPhosphoSitePlus
S1130ATAVDsDDIQTSETPhosphoSitePlus
S501PGSVGsGHSSPPhosphoSitePlus
S1066YGYNPsPVKPEHPRD; phosphoELM; SysPTM
S468PAPPLsPQAGDPhosphoSitePlus
S1179GIAIKsTNMASphosphoELM
S134DDDVLsIDSGDPhosphoSitePlus
S1140TISSGsEGDDFSETPhosphoSitePlus
T838AGKILtDDFADSETPhosphoSitePlus
T838AGKILtDDFADphosphoELM
S350MVLLKsGQLIKPhosphoSitePlus
S474PQAGDsDLESQPhosphoSitePlus
S872KEGYEsDAPCSSETPhosphoSitePlus
S112YRDSSsEDESSPhosphoSitePlus
S1066YGYNPsPVKPESETPhosphoSitePlus; SysPTM
S906SNDDSsDDNFCSETPhosphoSitePlus
Y230GPGKKyKVKFDPhosphoSitePlus
T1106TLSSStESEGESETPhosphoSitePlus
Y673RKFQPyKPFYYPhosphoSitePlus
S1103DVLTLsSSTESSETPhosphoSitePlus
T1197PVRKNtRQFYDHPRD
T1123PTAGQtSATAVSETPhosphoSitePlus
T1101PDDVLtLSSSTSETPhosphoSitePlus
T1180IAIKStNMASVSETPhosphoSitePlus
S1190VDKGEsAPVRKSETPhosphoSitePlus
S1137DIQTIsSGSEGSETPhosphoSitePlus
S110LQYRDsSSEDEPhosphoSitePlus
T1119TSRKPtAGQTSSETPhosphoSitePlus
S137VLSIDsGDAGSPhosphoSitePlus
T1135SDDIQtISSGSSETPhosphoSitePlus
S505GSGHSsPTSPAPhosphoSitePlus
S175AVNKKsSSQDLPhosphoSitePlus
S1190VDKGEsAPVRKHPRD; phosphoELM
S862LDHIEsVENFKSETPhosphoSitePlus
S1025EAEKAsTSGLGSETPhosphoSitePlus

Dephosphorylation site
SETB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000271640Q55RBIOMARTBreast Cancer21930507, 21930502
ENSP00000357958E74QBIOMARTBreast Cancer21930507, 21930502
ENSP00000271640R394WBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000271640E74QBIOMARTBreast Cancer21930507, 21930502
ENSP00000357958Q55RBIOMARTBreast Cancer21930507, 21930502
ENSP00000357965E74QBIOMARTBreast Cancer21930507, 21930502
ENSP00000271640T927PBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000271640S504CTCGAOvarian Cancer21720365, 18772890
ENSP00000357965Q55RBIOMARTBreast Cancer21930507, 21930502
ENSP00000271640Y304CTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
SETB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SETB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ARAF_HUMANSETB1_HUMANkinase -> substrateRobert H Newman (2013)
NLK_HUMANSETB1_HUMANphosphatase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00310Lysine degradation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0001833inner cell mass cell proliferationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0034968histone lysine methylationIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0018024histone-lysine N-methyltransferase activityIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005694chromosomeIEAcellular_component
GO:0005634nucleusIEAcellular_component


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