| UniProt/SwissProt ID: | SEM7A_HUMAN |
| Description: | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) [Source:HGNC Symbol;Acc:10741] |
| Location: | chr15 q24.1 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S275 | QGGESsLSVSK | Sema | PhosphoSitePlus |
| Dephosphorylation site |
| SEM7A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261918 | *667Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000261918 | E195D | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000261918 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 8.3 | 19199705 |
| Hyperphosphorylation site |
| SEM7A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SEM7A_HUMAN | PLXC1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0005178 | integrin binding | IEA | molecular_function |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0060907 | positive regulation of macrophage cytokine product | IEA | biological_process |
| GO:0050727 | regulation of inflammatory response | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0045773 | positive regulation of axon extension | IDA | biological_process |
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0007229 | integrin-mediated signaling pathway | IDA | biological_process |
| GO:0031225 | anchored to membrane | IEA | cellular_component |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IDA | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |