Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLXC1_HUMAN
Description:plexin C1 [Source:HGNC Symbol;Acc:9106]
Location:chr12 q22
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1350KVKEMyLTKLLPhosphoSitePlus
T683SNVIVtGANFTTIGPhosphoSitePlus
T1466GKEAPtNKLLYPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1146MSVCLsGFLREPhosphoSitePlus
Y1527TEIYKyIVKYFPhosphoSitePlus
S978LSRKQsQQLELPhosphoSitePlus
Y438PVKNIyIYLTAPhosphoSitePlus
Y566PTRATyKDVSVPhosphoSitePlus
T565IPTRAtYKDVSPhosphoSitePlus
Y440KNIYIyLTAGKPhosphoSitePlus
T1299ISNGStIKVFKHPRD
T562TCSIPtRATYKPhosphoSitePlus

Dephosphorylation site
PLXC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000258526V430ICOSMICOvarian Cancer21720365
ENSP00000258526A1058VCOSMICSkin Cancer21984974
ENSP00000258526D623ECOSMICHead and Neck Cancer21798893
ENSP00000258526R727WCOSMICHead and Neck Cancer21798893
ENSP00000258526V430ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000258526Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineUp215169874

Hyperphosphorylation site
PLXC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SEM7A_HUMANPLXC1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0004872receptor activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007155cell adhesionTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005102receptor bindingTASmolecular_function
GO:0016020membraneIEAcellular_component


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