| UniProt/SwissProt ID: | PLXC1_HUMAN |
| Description: | plexin C1 [Source:HGNC Symbol;Acc:9106] |
| Location: | chr12 q22 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1350 | KVKEMyLTKLL | PhosphoSitePlus | |
| T683 | SNVIVtGANFT | TIG | PhosphoSitePlus |
| T1466 | GKEAPtNKLLY | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S1146 | MSVCLsGFLRE | PhosphoSitePlus | |
| Y1527 | TEIYKyIVKYF | PhosphoSitePlus | |
| S978 | LSRKQsQQLEL | PhosphoSitePlus | |
| Y438 | PVKNIyIYLTA | PhosphoSitePlus | |
| Y566 | PTRATyKDVSV | PhosphoSitePlus | |
| T565 | IPTRAtYKDVS | PhosphoSitePlus | |
| Y440 | KNIYIyLTAGK | PhosphoSitePlus | |
| T1299 | ISNGStIKVFK | HPRD | |
| T562 | TCSIPtRATYK | PhosphoSitePlus | |
| Dephosphorylation site |
| PLXC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000258526 | V430I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000258526 | A1058V | COSMIC | Skin Cancer | 21984974 | ENSP00000258526 | D623E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000258526 | R727W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000258526 | V430I | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000258526 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 21 hour) | cell line | Up | 2 | 15169874 |
| Hyperphosphorylation site |
| PLXC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SEM7A_HUMAN | PLXC1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |