Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SEM3E_HUMAN
Description:sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [Source:HGNC Symbol;Acc:10727]
Location:chr7 q21.11
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y547ISCSRyYPTGTPSIPhosphoSitePlus
S509YIGSAsAVAQVPhosphoSitePlus

Dephosphorylation site
SEM3E_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000303212P490SCOSMICHead and Neck Cancer21984974
ENSP00000303212G54ECOSMICSkin Cancer21984974
ENSP00000303212P377QCOSMICHead and Neck Cancer21798893
ENSP00000303212V72LCOSMICOvarian Cancer21720365
ENSP00000303212P140SCOSMICSkin Cancer21984974

Differential expressed protein
SEM3E_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SEM3E_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SEM3E_HUMANPLXD1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0050808synapse organizationIEAbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0005615extracellular spaceTAScellular_component
GO:0016020membraneIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0002040sprouting angiogenesisIEAbiological_process
GO:0001953negative regulation of cell-matrix adhesionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:2000249regulation of actin cytoskeleton reorganizationIEAbiological_process
GO:0004872receptor activityIEAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0071526semaphorin-plexin signaling pathwayIEAbiological_process
GO:0016525negative regulation of angiogenesisIEAbiological_process


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