| UniProt/SwissProt ID: | SEM3E_HUMAN |
| Description: | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [Source:HGNC Symbol;Acc:10727] |
| Location: | chr7 q21.11 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y547 | ISCSRyYPTGT | PSI | PhosphoSitePlus |
| S509 | YIGSAsAVAQV | PhosphoSitePlus | |
| Dephosphorylation site |
| SEM3E_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000303212 | P490S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000303212 | G54E | COSMIC | Skin Cancer | 21984974 | ENSP00000303212 | P377Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000303212 | V72L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000303212 | P140S | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| SEM3E_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SEM3E_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SEM3E_HUMAN | PLXD1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001569 | patterning of blood vessels | IEA | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0050808 | synapse organization | IEA | biological_process |
| GO:0008360 | regulation of cell shape | IEA | biological_process |
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0002040 | sprouting angiogenesis | IEA | biological_process |
| GO:0001953 | negative regulation of cell-matrix adhesion | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:2000249 | regulation of actin cytoskeleton reorganization | IEA | biological_process |
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0071526 | semaphorin-plexin signaling pathway | IEA | biological_process |
| GO:0016525 | negative regulation of angiogenesis | IEA | biological_process |