| UniProt/SwissProt ID: | SDC3_HUMAN |
| Description: | syndecan 3 [Source:HGNC Symbol;Acc:10660] |
| Location: | chr1 p35.2 |
| Node attribute: | receptor; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y441 | KQEEF | phosphoELM | |
| Y441 | KQEEFyA | RegPhos | |
| Y409 | VTLLIyRMKKK | phosphoELM; RegPhos | |
| T234 | APSPPtTAAVL | Syndecan | PhosphoSitePlus |
| T245 | DTEAPtPRLVS | Syndecan | PhosphoSitePlus |
| Y409 | VTLLIyRMKKK | EPHB4 | HPRD |
| Y431 | QASVTyQKPDK | EPHB4 | HPRD |
| Y431 | QASVTyQKPDK | EphB4 | RegPhos |
| T349 | SSPPGtLPKGA | Syndecan | PhosphoSitePlus |
| Y431 | QASVTyQKPDK | phosphoELM; RegPhos | |
| Y419 | KDEGSyTLEEP | phosphoELM; RegPhos | |
| T146 | SPLVVtEVPEE | Syndecan | PhosphoSitePlus |
| Y419 | KDEGSyTLEEP | EphB4 | RegPhos |
| Y419 | KDEGSyTLEEP | EPHB4 | HPRD |
| Y409 | VTLLIyRMKKK | EphB4 | RegPhos |
| Y441 | KQEEFyA____ | PhosphoSitePlus | |
| Dephosphorylation site |
| SDC3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000344468 | T200S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000344468 | V103I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000344468 | S64C | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SDC3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SDC3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CO5A3_HUMAN | SDC3_HUMAN | ligand -> receptor | HPMR |
| EPHB4_HUMAN | SDC3_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | SDC3_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04512 | ECM-receptor interaction |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05144 | Malaria |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0043202 | lysosomal lumen | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0030203 | glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0006024 | glycosaminoglycan biosynthetic process | TAS | biological_process |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0006027 | glycosaminoglycan catabolic process | TAS | biological_process |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0008092 | cytoskeletal protein binding | IEA | molecular_function |
| GO:0030204 | chondroitin sulfate metabolic process | TAS | biological_process |