Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RYR1_HUMAN
Description:ryanodine receptor 1 (skeletal) [Source:HGNC Symbol;Acc:10483]
Location:chr19 q13.2
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T3494SDQERtKKKRRPhosphoSitePlus
T4826VKTLRtILSSVIon_transPhosphoSitePlus
S2459RAILRsLVPLEPhosphoSitePlus
T4823AMGVKtLRTILIon_transPhosphoSitePlus
Y2761NKFAEyTHEKWRyRPhosphoSitePlus
Y3131GQNLTyTTVALTMPhosphoSitePlus
S3951GKRNFsKAMSVRegPhos
S2594LSRGRsLTKAQPhosphoSitePlus
Y1733SMLSEyIVPLTPhosphoSitePlus
S2843KTRKIsQSAQTPKG_groupRegPhos
Y1965AFAERyVDKLQPhosphoSitePlus; HPRD
T2848SQSAQtYDPREPhosphoSitePlus
Y2935LQMNGyAVTRGRyRPhosphoSitePlus
S2843KTRKIsQSAQTPKACaRegPhos
T679LTAQAtHLRVGSPRYPhosphoSitePlus
S4829LRTILsSVTHNIon_transPhosphoSitePlus
S1731RRSMLsEYIVPPhosphoSitePlus
T4324RLRRLtAREAARegPhos
T4330AREAAtAVAALPhosphoSitePlus
S2843KTRKIsQSAQTPRKG1HPRD
S2843KTRKIsQSAQTPKG1RegPhos
Y245QRRLVyYEGGAMIRPhosphoSitePlus
T675VTPFLtAQATHSPRYPhosphoSitePlus
S2843KTRKIsQSAQTCaMK2gRegPhos
S3668LTEDHsFEDRMPhosphoSitePlus
S2843KTRKIsQSAQTPKA_groupRegPhos
T3133NLTYTtVALLPTMPhosphoSitePlus
S2863QPPDLsAVTLSRyRPhosphoSitePlus
S1728CRSRRsMLSEYPhosphoSitePlus
T4832ILSSVtHNGKQIon_transPhosphoSitePlus
Y2719YVDASySSKAEPhosphoSitePlus
T2762KFAEYtHEKWARyRPhosphoSitePlus
Y2426AIMSFyAALIDPhosphoSitePlus
Y1023PRLVPyRLLDERyRPhosphoSitePlus
T1399KVAMMtQPPATPhosphoSitePlus
S2868SAVTLsRELQARyRPhosphoSitePlus
T3177IYSLGtTKNTYPhosphoSitePlus
T3132QNLTYtTVALLTMPhosphoSitePlus
S781FFPVVsFSAGVSPRYPhosphoSitePlus
T3079SLDARtVMKSGHPRD; SysPTM
S2843KTRKIsQSAQTPRKACAHPRD
Y2696YDPELyRMAMPPhosphoSitePlus
S2843KTRKIsQSAQTPhosphoSitePlus
S3489IQSGGsDQERTPhosphoSitePlus
Y3921ICTVDyLLRLQPhosphoSitePlus
T3918NIIICtVDYLLPhosphoSitePlus
T3178YSLGTtKNTYVPhosphoSitePlus
T2596RGRSLtKAQRDPhosphoSitePlus
S4867KFYNKsEDEDEIon_transPhosphoSitePlus
S2843KTRKIsQSAQTCAMK2GHPRD
Y4864FFRKFyNKSEDIon_transPhosphoSitePlus
T2543TATFStTEMALPhosphoSitePlus

Dephosphorylation site
RYR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352608E187KCOSMICSkin Cancer21984974
ENSP00000352608S2948WTCGAOvarian Cancer21720365, 18772890
ENSP00000347667K1918IBIOMARTBreast Cancer21930507, 21930502
ENSP00000352608R1974WCOSMICOvarian Cancer21720365
ENSP00000352608R1827HCOSMICPancreatic Cancer
ENSP00000354254D4057YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000352608V347MCOSMICHead and Neck Cancer21798893
ENSP00000352608E3743GTCGAOvarian Cancer21720365, 18772890
ENSP00000352608S2948WCOSMICOvarian Cancer21720365
ENSP00000352608T3639MTCGAOvarian Cancer21720365, 18772890
ENSP00000347667D4057YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000352608S3314FCOSMICSkin Cancer21984974
ENSP00000352608E5VTCGAOvarian Cancer21720365, 18772890
ENSP00000352608T1899KCOSMICHead and Neck Cancer21798893
ENSP00000352608G3854RCOSMICSkin Cancer21984974
ENSP00000352608E3743GCOSMICOvarian Cancer21720365
ENSP00000352608E4691VTCGAOvarian Cancer21720365, 18772890
ENSP00000354254R819QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000352608E4691VCOSMICOvarian Cancer21720365
ENSP00000352608G1184WCOSMICOvarian Cancer21720365
ENSP00000352608T3639MCOSMICOvarian Cancer21720365
ENSP00000352608R163CCOSMICMelanoma21499247
ENSP00000354254K1918IBIOMARTBreast Cancer21930507, 21930502
ENSP00000352608Q1837HCOSMICHepatocellular Carcinoma21822264
ENSP00000352608M1647ICOSMICHead and Neck Cancer21798893
ENSP00000347667E1250KBIOMARTGastric Cancer21930507, 21930502
ENSP00000352608A1960SCOSMICOvarian Cancer21720365
ENSP00000352608E5VCOSMICOvarian Cancer21720365
ENSP00000352608K1918IBIOMARTBreast Cancer21930507, 21930502
ENSP00000352608A3541TCOSMICOvarian Cancer21720365
ENSP00000352608D4062YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000352608G4895DCOSMICHead and Neck Cancer21984974
ENSP00000352608M80KCOSMICOvarian Cancer21720365

Differential expressed protein
RYR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RYR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRYR1_HUMANkinase -> substrateRegPhos
KCC2G_HUMANRYR1_HUMANkinase -> substrateHPRD
KPCA_HUMANRYR1_HUMANkinase -> substrateHPRD
KGP1_HUMANRYR1_HUMANkinase -> substrateHPRD
BST1_HUMANRYR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04730Long-term depression

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043234protein complexIEAcellular_component
GO:0015278calcium-release channel activityTASmolecular_function
GO:0002020protease bindingIEAmolecular_function
GO:0031000response to caffeineIEAbiological_process
GO:0006811ion transportIEAbiological_process
GO:0051480cytosolic calcium ion homeostasisIEAbiological_process
GO:0016529sarcoplasmic reticulumIEAcellular_component
GO:0005938cell cortexIDAcellular_component
GO:0031674I bandIDAcellular_component
GO:0005219ryanodine-sensitive calcium-release channel activiIEAmolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0005262calcium channel activityIEAmolecular_function
GO:0048741skeletal muscle fiber developmentIEAbiological_process
GO:0043931ossification involved in bone maturationISSbiological_process
GO:0005245voltage-gated calcium channel activityISSmolecular_function
GO:0006936muscle contractionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051209release of sequestered calcium ion into cytosolIEAbiological_process
GO:0048741skeletal muscle fiber developmentISSbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0033017sarcoplasmic reticulum membraneIEAcellular_component
GO:0033017sarcoplasmic reticulum membraneISScellular_component
GO:0006936muscle contractionISSbiological_process
GO:0071313cellular response to caffeineISSbiological_process
GO:0005790smooth endoplasmic reticulumTAScellular_component
GO:0051480cytosolic calcium ion homeostasisISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0001666response to hypoxiaIDAbiological_process
GO:0071313cellular response to caffeineIEAbiological_process
GO:0005219ryanodine-sensitive calcium-release channel activiISSmolecular_function
GO:0030314junctional membrane complexIEAcellular_component
GO:0014802terminal cisternaISScellular_component
GO:0005216ion channel activityIEAmolecular_function
GO:0014701junctional sarcoplasmic reticulum membraneTAScellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0043588skin developmentIEAbiological_process
GO:0043588skin developmentISSbiological_process
GO:0031000response to caffeineISSbiological_process
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0003151outflow tract morphogenesisISSbiological_process
GO:0030315T-tubuleIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0014808release of sequestered calcium ion into cytosol byIEAbiological_process
GO:0055085transmembrane transportIEAbiological_process
GO:0016529sarcoplasmic reticulumISScellular_component
GO:0014808release of sequestered calcium ion into cytosol byISSbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0006816calcium ion transportISSbiological_process
GO:0043931ossification involved in bone maturationIEAbiological_process
GO:0005262calcium channel activityISSmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0051209release of sequestered calcium ion into cytosolISSbiological_process
GO:0005516calmodulin bindingISSmolecular_function
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0005245voltage-gated calcium channel activityIEAmolecular_function
GO:0006816calcium ion transportIEAbiological_process