| UniProt/SwissProt ID: | RXFP2_HUMAN |
| Description: | relaxin/insulin-like family peptide receptor 2 [Source:HGNC Symbol;Acc:17318] |
| Location: | chr13 q13.1 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| RXFP2_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| RXFP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000298386 | T103P | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000298386 | K699* | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| RXFP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RXFP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| REL1_HUMAN | RXFP2_HUMAN | ligand -> receptor | HPMR |
| REL2_HUMAN | RXFP2_HUMAN | ligand -> receptor | HPMR |
| INSL3_HUMAN | RXFP2_HUMAN | ligand -> receptor | HPMR |
| GLHA_HUMAN | RXFP2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008285 | negative regulation of cell proliferation | IEA | biological_process |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001556 | oocyte maturation | IEA | biological_process |
| GO:0016500 | protein-hormone receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0008584 | male gonad development | IEA | biological_process |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | IEA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0030819 | positive regulation of cAMP biosynthetic process | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0017046 | peptide hormone binding | IEA | molecular_function |