Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RUFY1_HUMAN
Description:RUN and FYVE domain containing 1 [Source:HGNC Symbol;Acc:19760]
Location:chr5 q35.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S618MGLHLsQSKLKBaculo_IE-1PhosphoSitePlus
S344LQEELsAATDRDUF972PhosphoSitePlus
S80GNLSAsCGSALPhosphoSitePlus
Y389VELETyKQTRQBMXphosphoELM; RegPhos
T192ASDIAtSVRNLRUNPhosphoSitePlus
S165LKVKKsFIGQNRUNPhosphoSitePlus
Y400GLDEMySDVWKRegPhos
Y389VELETyKQTRQRegPhos
S193SDIATsVRNLPRUNPhosphoSitePlus
T74LARRAtGNLSAPhosphoSitePlus
S352TDRICsLQEEQDUF972PhosphoSitePlus
S510MGLHLsQSKLKHPRD
S123HMMKLsIKVLLPhosphoSitePlus
Y389VELETyKQTRQDUF972PhosphoSitePlus
T347ELSAAtDRICSDUF972PhosphoSitePlus
S188LCPEAsDIATSRUNPhosphoSitePlus
Y400GLDEMySDVWKBMXphosphoELM; RegPhos
Y400GLDEMySDVWKDUF972PhosphoSitePlus
S618MGLHLsQSKLKHPRD; phosphoELM; RegPhos
S83SASCGsALRAAPhosphoSitePlus
S319LNRHLsCTVGDPhosphoSitePlus

Dephosphorylation site
RUFY1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377087T227STCGAOvarian Cancer21720365, 18772890
ENSP00000390025T227STCGAOvarian Cancer21720365, 18772890

Differential expressed protein
RUFY1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RUFY1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BMX_HUMANRUFY1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANRUFY1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008565protein transporter activityIEAmolecular_function
GO:0008289lipid bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0015031protein transportIEAbiological_process
GO:0006897endocytosisIEAbiological_process
GO:0031901early endosome membraneIEAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0030100regulation of endocytosisIEAbiological_process
GO:0005515protein bindingIPImolecular_function


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