| UniProt/SwissProt ID: | RUFY1_HUMAN |
| Description: | RUN and FYVE domain containing 1 [Source:HGNC Symbol;Acc:19760] |
| Location: | chr5 q35.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S618 | MGLHLsQSKLK | Baculo_IE-1 | PhosphoSitePlus |
| S344 | LQEELsAATDR | DUF972 | PhosphoSitePlus |
| S80 | GNLSAsCGSAL | PhosphoSitePlus | |
| Y389 | VELETyKQTRQ | BMX | phosphoELM; RegPhos |
| T192 | ASDIAtSVRNL | RUN | PhosphoSitePlus |
| S165 | LKVKKsFIGQN | RUN | PhosphoSitePlus |
| Y400 | GLDEMySDVWK | RegPhos | |
| Y389 | VELETyKQTRQ | RegPhos | |
| S193 | SDIATsVRNLP | RUN | PhosphoSitePlus |
| T74 | LARRAtGNLSA | PhosphoSitePlus | |
| S352 | TDRICsLQEEQ | DUF972 | PhosphoSitePlus |
| S510 | MGLHLsQSKLK | HPRD | |
| S123 | HMMKLsIKVLL | PhosphoSitePlus | |
| Y389 | VELETyKQTRQ | DUF972 | PhosphoSitePlus |
| T347 | ELSAAtDRICS | DUF972 | PhosphoSitePlus |
| S188 | LCPEAsDIATS | RUN | PhosphoSitePlus |
| Y400 | GLDEMySDVWK | BMX | phosphoELM; RegPhos |
| Y400 | GLDEMySDVWK | DUF972 | PhosphoSitePlus |
| S618 | MGLHLsQSKLK | HPRD; phosphoELM; RegPhos | |
| S83 | SASCGsALRAA | PhosphoSitePlus | |
| S319 | LNRHLsCTVGD | PhosphoSitePlus | |
| Dephosphorylation site |
| RUFY1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377087 | T227S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000390025 | T227S | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| RUFY1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RUFY1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BMX_HUMAN | RUFY1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | RUFY1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008565 | protein transporter activity | IEA | molecular_function |
| GO:0008289 | lipid binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0006897 | endocytosis | IEA | biological_process |
| GO:0031901 | early endosome membrane | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0030100 | regulation of endocytosis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |