Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RPGF1_HUMAN
Description:Rap guanine nucleotide exchange factor (GEF) 1 [Source:HGNC Symbol;Acc:4568]
Location:chr9 q34.13
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y61FLPEGyPLPLDPhosphoSitePlus
T950EWQKQtSEGLARasGEFPhosphoSitePlus
T572SMFYQtPQNEHPhosphoSitePlus
Y561QLLEDySEPQPPhosphoSitePlus
T328PMSRAtSGSSLHPRD
S966IDSSSsFRAYRRasGEFPhosphoSitePlus
S293PKKRQsAPSPTPhosphoSitePlus
T127LRYFKtIVDKMHPRD
S314ATSGSsLPVGIPhosphoSitePlus; HPRD; RegPhos
S378GKLSKsDEQLSHPRD
S345SYGGEsPRLSPPhosphoSitePlus
S965LIDSSsSFRAYRasGEFPhosphoSitePlus
Y390HYDPDyEFLQQPhosphoSitePlus
Y504IPSVPyAPFAAHCKHPRD; phosphoELM; RegPhos
Y504IPSVPyAPFAASrcRegPhos
S307VVAPMsRATSGPhosphoSitePlus
Y504IPSVPyAPFAASRCphosphoELM
S352RLSPCsSIGKLPhosphoSitePlus
S652ERAPKsPDALEPhosphoSitePlus
S296RQSAPsPTRVAPhosphoSitePlus
S951WQKQTsEGLAERasGEFPhosphoSitePlus
T298SAPSPtRVAVVHPRD
Y522IPSVPyAPFAAHCKHPRD
T261LLPDAtDEEVAPhosphoSitePlus
S463EKKRRsAASQTPhosphoSitePlus
T1067KPRNItRRKTDPhosphoSitePlus
Y715KDLVLyCEAFLRasGEF_NPhosphoSitePlus
S332ATSGSsLPVGIHPRD
T316SAPSPtRVAVVHPRD
S349ESPRLsPCSSIPhosphoSitePlus
Y329FDVDCyAQRRLPhosphoSitePlus
S360GKLSKsDEQLSPhosphoSitePlus; HPRD; RegPhos
S311MSRATsGSSLPPhosphoSitePlus; HPRD; RegPhos
Y570QPSMFyQTPQNPhosphoSitePlus
T109LRYFKtIVDKMPhosphoSitePlus; HPRD
T819LLRCAtSSQPLPhosphoSitePlus
T310PMSRAtSGSSLPhosphoSitePlus; HPRD; RegPhos
S820LRCATsSQPLAPhosphoSitePlus
S281RVVDNsPPPALPhosphoSitePlus
S466RRSAAsQTADGPhosphoSitePlus
S423LGESGsPFLGPPhosphoSitePlus
Y579QNEHIyQQKNKPhosphoSitePlus
S329MSRATsGSSLPHPRD
Y723AFLTTyRTFISRasGEF_NPhosphoSitePlus
S371SLDRDsGQCSRPhosphoSitePlus
S335AQRRLsGGSHSPhosphoSitePlus
T1071ITRRKtDREEKPhosphoSitePlus
Y504IPSVPyAPFAAPhosphoSitePlus; phosphoELM

Dephosphorylation site
RPGF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361264S908FCOSMICMelanoma
ENSP00000361264F39LCOSMICLung Cancer18948947
ENSP00000361264G846WCOSMICOvarian Cancer21720365
ENSP00000361264K940ECOSMICOvarian Cancer21720365
ENSP00000361264P76TCOSMICLung Cancer20668451

Differential expressed protein
RPGF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RPGF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HCK_HUMANRPGF1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANRPGF1_HUMANkinase -> substrateRegPhos
RPGF1_HUMANRHOQ_HUMANotherKEGG
RPGF1_HUMANRAP1A_HUMANotherKEGG
CRK_HUMANRPGF1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa04510Focal adhesion
hsa05211Renal cell carcinoma
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016337cell-cell adhesionIEAbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0007165signal transductionNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005768endosomeTAScellular_component
GO:0000186activation of MAPKK activityTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0017124SH3 domain bindingIEAmolecular_function


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