Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ROR2_HUMAN
Description:receptor tyrosine kinase-like orphan receptor 2 [Source:HGNC Symbol;Acc:10257]
Location:chr9 q22.31
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S449LMASPsQDMEMPhosphoSitePlus; HPRD; phosphoELM
S782PVSNVsNARYVPhosphoSitePlus
S447RQLMAsPSQDMPhosphoSitePlus; HPRD
Y755GNLSNyNSSAQPhosphoSitePlus
S758SNYNSsAQTSGPhosphoSitePlus
Y873STSTGyVTTAPPhosphoSitePlus
S469KLKEIsLSAVRHPRD
Y824VPVNGyQPVPAPhosphoSitePlus
Y646YAADYyKLLGNPkinase_TyrPhosphoSitePlus
S762SSAQTsGASNTPhosphoSitePlus
T438KASAStPQRRQPhosphoSitePlus
Y666PEAIMyGKFSIPkinase_TyrPhosphoSitePlus

Dephosphorylation site
ROR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364860C728SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000364860E357*Greenman2007Lung Cancer17344846, 18428421
ENSP00000364860P799SDing2008Lung Cancer18948947
ENSP00000364860V542MGreenman2007Intestines Cancer17344846, 18428421
ENSP00000364860R581GDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000364860P799SBIOMARTLung Cancer21930507, 21930502
ENSP00000364860V542MHPIColorectal Cancer17344846
ENSP00000364860G788WDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000364860P828TDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000364860Lung CancerNormal vs. CancertissueUp2.217705522
ENSP00000364860Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ROR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANROR2_HUMANkinase -> substrateNetPath
GSK3A_HUMANROR2_HUMANkinase -> substrateNetPath
ROR2_HUMAN1433B_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
ROR2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0017147Wnt-protein bindingIEAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0060071Wnt receptor signaling pathway, planar cell polariIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007254JNK cascadeIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0001502cartilage condensationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0017147Wnt-protein bindingIPImolecular_function
GO:0005109frizzled bindingIEAmolecular_function
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0030538embryonic genitalia morphogenesisIEAbiological_process
GO:0001756somitogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0007223Wnt receptor signaling pathway, calcium modulatingIEAbiological_process