| UniProt/SwissProt ID: | RNPS1_HUMAN |
| Description: | RNA binding protein S1, serine-rich domain [Source:HGNC Symbol;Acc:10080] |
| Location: | chr16 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T161 | PSPKPtKVHIG | PhosphoSitePlus; phosphoELM; RegPhos | |
| S125 | SSGSPsPSRRR | PhosphoSitePlus; RegPhos; SysPTM | |
| S281 | SPRRRsPVRRR | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S97 | GSSSGsSSSSA | PhosphoSitePlus | |
| S53 | ATKESsEKDRG | PhosphoSitePlus | |
| S289 | RRRSRsPGRRR | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S77 | SSSTRsRSSST | PhosphoSitePlus | |
| T29 | RAPSPtKRKDR | PhosphoSitePlus | |
| S22 | NNKKSsTRAPS | PhosphoSitePlus | |
| S27 | STRAPsPTKRK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S10 | GVKKKsLLGVK | PhosphoSitePlus | |
| S35 | KRKDRsDEKSK | PhosphoSitePlus; HPRD | |
| S53 | ATKESsEKDRG | CK2a1(CK2 alpha | RegPhos |
| S81 | RSRSSsTSSSG | PhosphoSitePlus | |
| S94 | TSTGSsSGSSS | PhosphoSitePlus | |
| S141 | RSRSKsKPPKR | PhosphoSitePlus; HPRD | |
| S95 | STGSSsGSSSS | PhosphoSitePlus | |
| S266 | PMWRRsPPRMR | PhosphoSitePlus; phosphoELM; RegPhos | |
| T23 | NKKSStRAPSP | PhosphoSitePlus; HPRD | |
| T91 | GSSTStGSSSG | PhosphoSitePlus | |
| S157 | KRRSPsPKPTK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S88 | SSSGSsTSTGS | PhosphoSitePlus | |
| S287 | PVRRRsRSPGR | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y205 | HLSKGyAYVEF | HPRD; phosphoELM; RegPhos | |
| S98 | SSSGSsSSSAS | PhosphoSitePlus | |
| S85 | SSTSSsGSSTS | PhosphoSitePlus | |
| T82 | SRSSStSSSGS | PhosphoSitePlus | |
| S70 | RRSASsGSSST | PhosphoSitePlus | |
| S101 | GSSSSsASSRS | PhosphoSitePlus | |
| S182 | IMEIFsTYGKI | HPRD | |
| S87 | TSSSGsSTSTG | PhosphoSitePlus | |
| Y205 | HLSKGyAYVEF | RRM_1 | PhosphoSitePlus |
| S104 | SSSASsRSGSS | PhosphoSitePlus | |
| S67 | TRKRRsASSGS | PhosphoSitePlus | |
| S53 | ATKESsEKDRG | CK2_alpha | phosphoELM |
| S155 | ERKRRsPSPKP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S251 | PPRRFsPPRRM | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S90 | SGSSTsTGSSS | PhosphoSitePlus | |
| T89 | SSGSStSTGSS | PhosphoSitePlus | |
| S103 | SSSSAsSRSGS | PhosphoSitePlus | |
| S53 | ATKESsEKDRG | CK2_group | RegPhos |
| S83 | RSSSTsSSGSS | PhosphoSitePlus | |
| S93 | STSTGsSSGSS | PhosphoSitePlus | |
| S52 | GATKEsSEKDR | HPRD | |
| Y207 | SKGYAyVEFEN | RRM_1 | PhosphoSitePlus |
| Dephosphorylation site |
| RNPS1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000380275 | E232D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000380275 | E217K | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RNPS1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RNPS1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KCC4_HUMAN | RNPS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CSK21_HUMAN | RNPS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | RNPS1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03015 | mRNA surveillance pathway |
| hsa03013 | RNA transport |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsen | IDA | biological_process |
| GO:0003730 | mRNA 3'-UTR binding | IDA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006406 | mRNA export from nucleus | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0035145 | exon-exon junction complex | TAS | cellular_component |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006369 | termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | TAS | biological_process |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0031124 | mRNA 3'-end processing | TAS | biological_process |