| UniProt/SwissProt ID: | RND1_HUMAN |
| Description: | Rho family GTPase 1 [Source:HGNC Symbol;Acc:18314] |
| Location: | chr12 q13.12 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S192 | CLNKPsPLPQK | PhosphoSitePlus | |
| S212 | LLHLPsRSELI | PhosphoSitePlus | |
| S184 | IFRTAsMLCLN | PhosphoSitePlus | |
| T182 | HSIFRtASMLC | Ras | PhosphoSitePlus |
| S140 | TLMELsHQKQA | Ras | PhosphoSitePlus |
| Dephosphorylation site |
| RND1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000308461 | E150D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000308461 | C14F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RND1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RND1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG12_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007162 | negative regulation of cell adhesion | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0005912 | adherens junction | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0007015 | actin filament organization | IDA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0006184 | GTP catabolic process | NAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0016322 | neuron remodeling | IDA | biological_process |
| GO:0005102 | receptor binding | IPI | molecular_function |
| GO:0003924 | GTPase activity | NAS | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |