| UniProt/SwissProt ID: | RIR2B_HUMAN |
| Description: | ribonucleotide reductase M2 B (TP53 inducible) [Source:HGNC Symbol;Acc:17296] |
| Location: | chr8 q22.3 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S225 | SNELIsRDEGL | Ribonuc_red_sm | PhosphoSitePlus |
| S72 | EEVDLsKDLPH | Ribonuc_red_sm | PhosphoSitePlus |
| Y331 | KRVSEyQRFAV | PhosphoSitePlus | |
| Dephosphorylation site |
| RIR2B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000251810 | K166N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000251810 | H91Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000251810 | V115L | HPI | Colorectal Cancer | 11719458 | ENSP00000251810 | S25G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000251810 | Uterine Cancer | Treatment(none vs. transfected with the pOP13 vector that containing E7) | cell line | Down | 14997504 | |
| Hyperphosphorylation site |
| RIR2B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | RIR2B_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00240 | Pyrimidine metabolism |
| hsa00480 | Glutathione metabolism |
| hsa01100 | Metabolic pathways |
| hsa04115 | p53 signaling pathway |
| hsa00230 | Purine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0055086 | nucleobase-containing small molecule metabolic pro | TAS | biological_process |
| GO:0001822 | kidney development | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006979 | response to oxidative stress | IEA | biological_process |
| GO:0009263 | deoxyribonucleotide biosynthetic process | IEA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0009186 | deoxyribonucleoside diphosphate metabolic process | IEA | biological_process |
| GO:0005971 | ribonucleoside-diphosphate reductase complex | IEA | cellular_component |
| GO:0046914 | transition metal ion binding | IEA | molecular_function |
| GO:0006264 | mitochondrial DNA replication | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0015949 | nucleobase-containing small molecule interconversi | TAS | biological_process |
| GO:0004748 | ribonucleoside-diphosphate reductase activity, thi | IEA | molecular_function |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0003014 | renal system process | IEA | biological_process |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0009200 | deoxyribonucleoside triphosphate metabolic process | IEA | biological_process |