Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RFX4_HUMAN
Description:regulatory factor X, 4 (influences HLA class II expression) [Source:HGNC Symbol;Acc:9985]
Location:chr12 q23.3
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S653FNSPTsRMEPCPhosphoSitePlus
Y129QSKYHyYGIAVRFX_DNA_bindingPhosphoSitePlus
Y140KESSQyYDVMYPhosphoSitePlus
S40SLGNVsNDENEPhosphoSitePlus
Y168KQTVAySPRSKPhosphoSitePlus
Y364TKQTLyTMEDSPhosphoSitePlus
Y127RGQSKyHYYGIRFX_DNA_bindingPhosphoSitePlus
T215QRILDtVIRANPhosphoSitePlus
S325LRRQTsLNHLCPhosphoSitePlus
S333HLCQAsRTVIHPhosphoSitePlus
Y130SKYHYyGIAVKRFX_DNA_bindingPhosphoSitePlus

Dephosphorylation site
RFX4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000350552S366NBIOMARTBreast Cancer21930507, 21930502
ENSP00000229387D533YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000350552D636YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000376585S357NBIOMARTBreast Cancer21930507, 21930502
ENSP00000229387C339RBIOMARTBreast Cancer21930507, 21930502
ENSP00000350552C442RBIOMARTBreast Cancer21930507, 21930502
ENSP00000376585D627YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000229387S263NBIOMARTBreast Cancer21930507, 21930502
ENSP00000376585C433RBIOMARTBreast Cancer21930507, 21930502
ENSP00000376585H386NCOSMICHead and Neck Cancer21798897

Differential expressed protein
RFX4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RFX4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RFX4_HUMANIL5RA_HUMANTF -> target geneTRANSFAC
RFX4_HUMANDRA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
RFX4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0021516dorsal spinal cord developmentIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030900forebrain developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0021696cerebellar cortex morphogenesisIEAbiological_process
GO:0030901midbrain developmentIEAbiological_process


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